Human MBL2 Recombinant Protein (RPPB3937)
- SKU:
- RPPB3937
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P11226
Description
| Product Name: | Human MBL2 Recombinant Protein |
| Product Code: | RPPB3937 |
| Size: | 20µg |
| Species: | Human |
| Target: | MBL2 |
| Synonyms: | COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, Mannose-binding protein C, Collectin-1, Mannan-binding protein, Mannose-binding lectin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MBL2 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea, 20% glycerol and 0.2M Nacl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSAASERKA LQTEMARIKK WLTFSLGKQV GNKFFLTNGE IMTFEKVKAL CVKFQASVAT PRNAAENGAI QNLIKEEAFL GITDEKTEGQ FVDLTGNRLT YTNWNEGEPN NAGSDEDCVL LLKNGQWNDV PCSTSHLAVC EFPI |
Mannose-binding protein C (MBL2),belongs to the collectin family of patternrecognition molecules and is an important component in the innate immune system. MBL2 is a secreted glycoprotein which recognizes mannose and N-acetylglucosamine on various microorganisms, and is capable of activating the classical complement pathway. Lacking MBL2 has been associated with susceptibility to autoimmune and infectious diseases.
MBL2 Human Recombinant produced in E. coli is a single polypeptide chain containing 164 amino acids (108-248) and having a molecular mass of 18 kDa. MBL2 is fused to 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: extracellular space; cell surface; collagen; extracellular region Molecular Function:mannose binding; protein binding; calcium ion binding; calcium-dependent protein binding; receptor binding Biological Process: defense response to Gram-positive bacterium; killing by host of symbiont cells; positive regulation of phagocytosis; defense response to bacterium; acute-phase response; innate immune response; response to oxidative stress; opsonization; complement activation, lectin pathway; complement activation, classical pathway; negative regulation of viral reproduction; complement activation Disease: Mannose-binding Protein Deficiency |
| NCBI Summary: | This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11226 |
| NCBI GenInfo Identifier: | 4557739 |
| NCBI Gene ID: | 4153 |
| NCBI Accession: | NP_000233.1 |
| UniProt Secondary Accession: | P11226,Q4VB12, Q4VB13, Q86SI4, Q96KE4, Q96TF7, Q96TF8 Q96TF9, |
| UniProt Related Accession: | P11226 |
| Molecular Weight: | 26,144 Da |
| NCBI Full Name: | mannose-binding protein C |
| NCBI Synonym Full Names: | mannose-binding lectin (protein C) 2, soluble |
| NCBI Official Symbol: | MBL2�� |
| NCBI Official Synonym Symbols: | MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC�� |
| NCBI Protein Information: | mannose-binding protein C; collectin-1; mannan-binding lectin; mannose-binding lectin 2, soluble (opsonic defect); mannose-binding lectin (protein C) 2, soluble (opsonic defect) |
| UniProt Protein Name: | Mannose-binding protein C |
| UniProt Synonym Protein Names: | Collectin-1; MBP1; Mannan-binding protein; Mannose-binding lectin |
| Protein Family: | Mannose-binding protein |
| UniProt Gene Name: | MBL2�� |
| UniProt Entry Name: | MBL2_HUMAN |
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