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Human MAGEA8 Recombinant Protein (RPPB3914)

SKU:
RPPB3914
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P43361
€309
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Description

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Product Name:Human MAGEA8 Recombinant Protein
Product Code:RPPB3914
Size:10µg
Species:Human
Target:MAGEA8
Synonyms:Melanoma Antigen Family A8, MAGE-8 Antigen, MAGE8, Cancer/Testis Antigen 1.8, CT1.8, Cancer/Testis Antigen Family 1, Member 8, Cancer/Testis Antigen Family 1, Melanoma-Associated Antigen 8, Melanoma Antigen Family A, 8, Member 8, MAGEA8.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MAGEA8 protein solution (0.25mg/ml) containing Phosphate Buffered Saline, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMLLGQKS QRYKAEEGLQ AQGEAPGLMD VQIPTAEEQK AASSSSTLIM GTLEEVTDSG SPSPPQSPEG ASSSLTVTDS TLWSQSDEGS SSNEEEGPST SPDPAHLESL FREALDEKVA ELVRFLLRKY QIKEPVTKAE MLESVIKNYK NHFPDIFSKA SECMQVIFGI DVKEVDPAGH SYILVTCLGL SYDGLLGDDQ STPKTGLLII VLGMILMEGS RAPEEAIWEA LSVMGLYDGR EHSVYWKLRK LLTQEWVQEN YLEYRQAPGS DPVRYEFLWG PRALAETSYV KVLEHVVRVN ARVRISYPSL HEEALGEEKG V

Melanoma Antigen Family A 8, also known as MAGEA8 belongs to the MAGEgene family, which includes twelve known genes, of which six are expressed intumors. Furthermore, the MAGE genes were at first isolated from different kindsof tumors, and according to their virtually exclusive tumor-specific expressionin adult tissues, they have been used as targets for cancer immunotherapy.

MAGEA8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 341 amino acids (1-318 a.a) and having a molecular mass of 37.6kDa.MAGEA8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
UniProt Protein Details:
NCBI Summary:This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]
UniProt Code:P43361
NCBI GenInfo Identifier:261878488
NCBI Gene ID:4107
NCBI Accession:NP_001159872.1
UniProt Secondary Accession:P43361,Q9BUN9
UniProt Related Accession:P43361
Molecular Weight:34
NCBI Full Name:melanoma-associated antigen 8
NCBI Synonym Full Names:MAGE family member A8
NCBI Official Symbol:MAGEA8��
NCBI Official Synonym Symbols:CT1.8; MAGE8��
NCBI Protein Information:melanoma-associated antigen 8
UniProt Protein Name:Melanoma-associated antigen 8
UniProt Synonym Protein Names:Cancer/testis antigen 1.8; CT1.8; MAGE-8 antigen
Protein Family:
UniProt Gene Name:MAGEA8��
UniProt Entry Name:

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