Human MAD2L1BP Recombinant Protein (RPPB3904)
- SKU:
- RPPB3904
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15013
Description
| Product Name: | Human MAD2L1BP Recombinant Protein |
| Product Code: | RPPB3904 |
| Size: | 10µg |
| Species: | Human |
| Target: | MAD2L1BP |
| Synonyms: | MAD2L1-binding protein, Caught by MAD2 protein, MAD2L1BP, CMT2, KIAA0110, RP1-261G23.6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MAD2L1BP protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAAPEA EVLSSAAVPD LEWYEKSEET HASQIELLET SSTQEPLNAS EAFCPRDCMV PVVFPGPVSQ EGCCQFTCEL LKHIMYQRQQ LPLPYEQLKH FYRKPSPQAE EMLKKKPRAT TEVSSRKCQQ ALAELESVLS HLEDFFARTL VPRVLILLGGNALSPKEFYE LDLSLLAPYS VDQSLSTAAC LRRLFRAIFM ADAFSELQAP PLMGTVVMAQ GHRNCGEDWF RPKLNYRVPS RGHKLTVTLS CGRPSIRTTA WEDYIWFQAP VTFKGFRE |
MAD2L1-binding protein (MAD2L1BP) is a member of the MAD2L1BP family.MAD2L1BP is a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a fundamental factor of the spindle checkpoint which delays the onset of anaphase until all the kinetochores are connected to the spindle. The MAD2L1BP protein acts to curb the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 once it dissociated from the MAD2L1-CDC20 complex. For the duration of the cell cycle, MAD2L1BP levels increase and then remain constant until late mitosis after which they drop.
MAD2L1BP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids (1-274 a.a) and having a molecular mass of 33.6kDa (Molecular weight on SDS-PAGE will appear higher).MAD2L1BP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MAD2L1BP: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. Belongs to the MAD2L1BP family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 6p21.1Cellular Component: cytoplasm; nucleusMolecular Function: protein bindingBiological Process: mitotic cell cycle checkpoint; regulation of exit from mitosis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15013 |
| NCBI GenInfo Identifier: | 3123048 |
| NCBI Gene ID: | 9587 |
| NCBI Accession: | Q15013.1 |
| UniProt Secondary Accession: | Q15013,Q6IBB1, B4DLV3, E9PAT7 |
| UniProt Related Accession: | Q15013 |
| Molecular Weight: | 34,676 Da |
| NCBI Full Name: | MAD2L1-binding protein |
| NCBI Synonym Full Names: | MAD2L1 binding protein |
| NCBI Official Symbol: | MAD2L1BP�� |
| NCBI Official Synonym Symbols: | CMT2�� |
| NCBI Protein Information: | MAD2L1-binding protein |
| UniProt Protein Name: | MAD2L1-binding protein |
| UniProt Synonym Protein Names: | Caught by MAD2 protein |
| Protein Family: | MAD2L1-binding protein |
| UniProt Gene Name: | MAD2L1BP�� |
| UniProt Entry Name: | MD2BP_HUMAN |
