Human LZTFL1 Recombinant Protein (RPPB3899)
- SKU:
- RPPB3899
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NQ48
Description
| Product Name: | Human LZTFL1 Recombinant Protein |
| Product Code: | RPPB3899 |
| Size: | 20µg |
| Species: | Human |
| Target: | LZTFL1 |
| Synonyms: | Leucine Zipper Transcription Factor-Like 1, BBS17, LeucineZipper Transcription Factor-Like Protein 1, Leucine zipper transcriptionfactor-like protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LZTFL1 protein solution (1mg/ml) containing PBS buffer(pH 7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAELGLN EHHQNEVINY MRFARSKRGL RLKTVDSCFQ DLKESRLVEDTFTIDEVSEV LNGLQAVVHS EVESELINTA YTNVLLLRQL FAQAEKWYLK LQTDISELEN RELLEQVAEFEKAEITSSNK KPILDVTKPK LAPLNEGGTA ELLNKEILRL QEENEKLKSR LKTIEIQATN ALDEKSKLEKALQDLQLDQG NQKDFIKAQD LSNLENTVAA LKSEFQKTLN DKTENQKSLE ENLATAKHDL LRVQEQLHMAEKELEKKFQQ TAAYRNMKEI LTKKNDQIKD LRKRLAQYEP ED |
LeucineZipper Transcription Factor-Like 1, also known as LZTFL1 is a ubiquitouslyexpressed protein which localizes to the cytoplasm. LZTFL1 interacts with Bardet-BiedlSyndrome proteins (BBS) and during its interaction with BBS protein complexes,regulates protein trafficking to the ciliary membrane. Nonsense mutations inLZTFL1 cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized partlyby polydactyly, obesity, cognitive impairment, hypogonadism, and� kidney failure. LZTFL1 also acts as a tumorsuppressor; possibly by interacting with E-cadherin as well as the actin cytoskeletonand in this manner regulating the transition of epithelial cells to mesenchymalcells.
LZTFL1 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 322 amino acids (1-299 a.a) and having a molecularmass of 37.0kDa.LZTFL1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013] |
| UniProt Code: | Q9NQ48 |
| NCBI GenInfo Identifier: | 74734310 |
| NCBI Gene ID: | 54585 |
| NCBI Accession: | Q9NQ48.1 |
| UniProt Secondary Accession: | Q9NQ48,Q8TC61, Q9NQ56, B3KSI9, B4E0K7 |
| UniProt Related Accession: | Q9NQ48 |
| Molecular Weight: | 29,332 Da |
| NCBI Full Name: | Leucine zipper transcription factor-like protein 1 |
| NCBI Synonym Full Names: | leucine zipper transcription factor like 1 |
| NCBI Official Symbol: | LZTFL1�� |
| NCBI Official Synonym Symbols: | BBS17�� |
| NCBI Protein Information: | leucine zipper transcription factor-like protein 1 |
| UniProt Protein Name: | Leucine zipper transcription factor-like protein 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Leucine zipper transcription factor-like protein |
| UniProt Gene Name: | LZTFL1�� |
| UniProt Entry Name: | LZTL1_HUMAN |
