Human Lymphotactin Recombinant Protein (RPPB1182)
- SKU:
- RPPB1182
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P47992
- Research Area:
- Chemokines
Description
| Product Name: | Human Lymphotactin Recombinant Protein |
| Product Code: | RPPB1182 |
| Size: | 10µg |
| Species: | Human |
| Target: | Lymphotactin |
| Synonyms: | XCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | Recombinant XCL1 contains 20mM Tris buffer pH-8, 200mM NaCl, 2mM DTT and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVGSEVSDKR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG |
XCL1 is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is located in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.
XCL1 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 114 amino acids (22-114 a.a.) and having a molecular mass of 12.5 kDa. The XCL1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q23 Cellular Component: extracellular space; extracellular region Molecular Function:protein homodimerization activity; chemokine activity; chemokine receptor binding Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; response to virus; negative regulation of transcription factor activity; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; negative regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P47992 |
| NCBI GenInfo Identifier: | 1346471 |
| NCBI Gene ID: | 6375 |
| NCBI Accession: | P47992.1 |
| UniProt Secondary Accession: | P47992,Q52MA8, |
| UniProt Related Accession: | P47992 |
| Molecular Weight: | 12,517 Da |
| NCBI Full Name: | Lymphotactin |
| NCBI Synonym Full Names: | chemokine (C motif) ligand 1 |
| NCBI Official Symbol: | XCL1�� |
| NCBI Official Synonym Symbols: | LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a�� |
| NCBI Protein Information: | lymphotactin; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin) |
| UniProt Protein Name: | Lymphotactin |
| UniProt Synonym Protein Names: | ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1 |
| Protein Family: | Lymphotactin |
| UniProt Gene Name: | XCL1�� |
| UniProt Entry Name: | XCL1_HUMAN |
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