Human Lymphotactin Recombinant Protein (RPPB1181)
- SKU:
- RPPB1181
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P47992
- Research Area:
- Chemokines
Description
| Product Name: | Human Lymphotactin Recombinant Protein |
| Product Code: | RPPB1181 |
| Size: | 2x10µg |
| Species: | Human |
| Target: | Lymphotactin |
| Synonyms: | XCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The XCL1 was lyophilized from a concentrated (1mg/ml) solution in water containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Lymphotactin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Lymphotactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution XCL1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. |
| Purity: | Greater than 99.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Ser-Glu-Val-Ser |
| Biological Activity: | The Biological activity is calculated by its ability to chemoattract human T cells at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. |
Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose geneis found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.
Lymphotactin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 92 amino acids and having a molecular mass of 10007 Dalton. The Lymphotactin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q23 Cellular Component: extracellular space; extracellular region Molecular Function:protein homodimerization activity; chemokine activity; chemokine receptor binding Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; response to virus; negative regulation of transcription factor activity; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; negative regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P47992 |
| NCBI GenInfo Identifier: | 1346471 |
| NCBI Gene ID: | 6375 |
| NCBI Accession: | P47992.1 |
| UniProt Secondary Accession: | P47992,Q52MA8, |
| UniProt Related Accession: | P47992 |
| Molecular Weight: | 12,517 Da |
| NCBI Full Name: | Lymphotactin |
| NCBI Synonym Full Names: | chemokine (C motif) ligand 1 |
| NCBI Official Symbol: | XCL1�� |
| NCBI Official Synonym Symbols: | LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a�� |
| NCBI Protein Information: | lymphotactin; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin) |
| UniProt Protein Name: | Lymphotactin |
| UniProt Synonym Protein Names: | ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1 |
| Protein Family: | Lymphotactin |
| UniProt Gene Name: | XCL1�� |
| UniProt Entry Name: | XCL1_HUMAN |
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