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Human LY86 Recombinant Protein (RPPB3895)

SKU:
RPPB3895
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95711
€309
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Description

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Product Name:Human LY86 Recombinant Protein
Product Code:RPPB3895
Size:20µg
Species:Human
Target:LY86
Synonyms:Lymphocyte Antigen 86, MD-1 RP105-Associated, Protein MD-1, Ly-86, MMD-1, dJ80N2.1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The LY86 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSGGGGKAW PTHVVCSDSG LEVLYQSCDP LQDFGFSVEK CSKQLKSNIN IRFGIILRED IKELFLDLAL MSQGSSVLNF SYPICEAALP KFSFCGRRKG EQIYYAGPVN NPEFTIPQGE YQVLLELYTE KRSTVACANA TIMCS

LY86 is vital for effective CD180 cell surface expression and is vastly expressed in B-cells, tonsil and monocytes. LY86 collaborate with TLR4 and CD180 to facilitate the essential immune response to bacterial lipopolysaccharide (LPS) and cytokine production.

LY86 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (21-162) and having a molecular mass of 18.1kDa.LY86 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LY86: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Apoptosis

Chromosomal Location of Human Ortholog: 6p25.1

Cellular Component: plasma membrane

Biological Process: apoptosis; cell proliferation; humoral immune response; positive regulation of lipopolysaccharide-mediated signaling pathway

UniProt Code:O95711
NCBI GenInfo Identifier:20138465
NCBI Gene ID:9450
NCBI Accession:O95711.1
UniProt Secondary Accession:O95711,Q9UQC4,
UniProt Related Accession:O95711
Molecular Weight:17,906 Da
NCBI Full Name:Lymphocyte antigen 86
NCBI Synonym Full Names:lymphocyte antigen 86
NCBI Official Symbol:LY86��
NCBI Official Synonym Symbols:MD1; MD-1; MMD-1; dJ80N2.1��
NCBI Protein Information:lymphocyte antigen 86
UniProt Protein Name:Lymphocyte antigen 86
UniProt Synonym Protein Names:Protein MD-1
Protein Family:Lymphocyte antigen
UniProt Gene Name:LY86��
UniProt Entry Name:LY86_HUMAN

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