Human LSM5 Recombinant Protein (RPPB3886)
- SKU:
- RPPB3886
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y4Y9
Description
| Product Name: | Human LSM5 Recombinant Protein |
| Product Code: | RPPB3886 |
| Size: | 20µg |
| Species: | Human |
| Target: | LSM5 |
| Synonyms: | LSM5 homolog, U6 small nuclear RNA associated(S.cerevisiae), YER146W, U6 snRNA-associated Sm-like protein LSm5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | LSM5 protein solution (1mg/ml) containing 20mM Tris-HCl (pH8.5), 10% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAANATT NPSQLLPLEL VDKCIGSRIH IVMKSDKEIV GTLLGFDDFVNMVLEDVTEF EITPEGRRIT KLDQILLNGN NITMLVPGGE GPEV |
LSM5also known as LSM5 Homolog, U6 Small Nuclear RNA Associated belongs to the Smprotein family. This family is identified in a variety of organismsbased on sequence homology. Sm-like proteins contain the Sm sequence motif,which consists of 2 regions separated by a linker of variable length whichfolds as a loop. In addition, the Sm-like proteins are thought to create astable heteromer present in tri-snRNPparticles, which are important for pre-mRNA splicing. Among the diseasesassociated with LSM5 are spinal muscular atrophy, and muscular atrophy.
LSM5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 114 amino acids (1-91 a.a) and having a molecular mass of 12.3kDa.LSM5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LSM5: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. Belongs to the snRNP Sm proteins family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-binding; RNA processingChromosomal Location of Human Ortholog: 7p14.3Cellular Component: cytosol; nucleoplasm; nucleus; spliceosome; U4/U6 x U5 tri-snRNP complexMolecular Function: protein binding; RNA bindingBiological Process: mRNA processing; nuclear mRNA splicing, via spliceosome |
| UniProt Protein Details: | |
| NCBI Summary: | Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q9Y4Y9 |
| NCBI GenInfo Identifier: | 6912488 |
| NCBI Gene ID: | 23658 |
| NCBI Accession: | NP_036454.1 |
| UniProt Secondary Accession: | Q9Y4Y9 |
| UniProt Related Accession: | Q9Y4Y9 |
| Molecular Weight: | 6,850 Da |
| NCBI Full Name: | U6 snRNA-associated Sm-like protein LSm5 isoform a |
| NCBI Synonym Full Names: | LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated |
| NCBI Official Symbol: | LSM5�� |
| NCBI Official Synonym Symbols: | YER146W�� |
| NCBI Protein Information: | U6 snRNA-associated Sm-like protein LSm5 |
| UniProt Protein Name: | U6 snRNA-associated Sm-like protein LSm5 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Sm-like protein |
| UniProt Gene Name: | LSM5�� |
| UniProt Entry Name: | LSM5_HUMAN |
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