Human LSM2 Recombinant Protein (RPPB3883)
- SKU:
- RPPB3883
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y333
Description
| Product Name: | Human LSM2 Recombinant Protein |
| Product Code: | RPPB3883 |
| Size: | 20µg |
| Species: | Human |
| Target: | LSM2 |
| Synonyms: | LSM2 homolog U6 small nuclear RNA associated (S. cerevisiae), Small nuclear ribonuclear protein D homolog, chromosome 6 open reading frame 28, snRNP core Sm-like protein Sm-x5, C6orf28, YBL026W, Protein G7b, snRNP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The LSM2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM Nacl, 5mM DTT and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMLFYSF FKSLVGKDVV VELKNDLSIC GTLHSVDQYL NIKLTDISVT DPEKYPHMLS VKNCFIRGSV VRYVQLPADE VDTQLLQDAA RKEALQQKQ |
LSM2 is a member of the snRNP Sm proteins family. Sm-like proteins are branded in several organisms based on sequence homology with the Sm protein family. Sm-like proteins hold the Sm sequence motif that is made up of 2 regions separated by a linker of variable length which folds as a loop. The Sm-like proteins are believed to create a steady heteromer present in tri-snRNP particles, which are vital for pre-mRNA splicing. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA nad takes part in pre-mRNA splicing.
LSM2 Human Recombinant produced in�E. coli is a single polypeptide chain containing 119 amino acids (1-95) and having a molecular mass of 13.4kDa.LSM2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LSM2: Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing. Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome; RNA-binding Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: cytosol; nucleoplasm; U4/U6 x U5 tri-snRNP complex Molecular Function:protein binding; Ral GTPase binding; RNA binding Biological Process: nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9Y333 |
| NCBI GenInfo Identifier: | 10720079 |
| NCBI Gene ID: | 57819 |
| NCBI Accession: | Q9Y333.1 |
| UniProt Secondary Accession: | Q9Y333,Q6FGG1, |
| UniProt Related Accession: | Q9Y333 |
| Molecular Weight: | 10,835 Da |
| NCBI Full Name: | U6 snRNA-associated Sm-like protein LSm2 |
| NCBI Synonym Full Names: | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| NCBI Official Symbol: | LSM2�� |
| NCBI Official Synonym Symbols: | G7B; snRNP; C6orf28; YBL026W�� |
| NCBI Protein Information: | U6 snRNA-associated Sm-like protein LSm2 |
| UniProt Protein Name: | U6 snRNA-associated Sm-like protein LSm2 |
| UniProt Synonym Protein Names: | Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP core Sm-like protein Sm-x5 |
| Protein Family: | Sm-like protein |
| UniProt Gene Name: | LSM2�� |
| UniProt Entry Name: | LSM2_HUMAN |
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