Human LMO1 Recombinant Protein (RPPB3870)
- SKU:
- RPPB3870
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P25800
Description
| Product Name: | Human LMO1 Recombinant Protein |
| Product Code: | RPPB3870 |
| Size: | 10µg |
| Species: | Human |
| Target: | LMO1 |
| Synonyms: | Rhombotin-1, Cysteine-rich protein TTG-1, LIM domain only protein 1, T-cell translocation protein 1, RBTN1, RHOM1, TTG1, LMO-1, LMO1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | LMO1protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMMVLDKE DGVPMLSVQP KGKQKGCAGC NRKIKDRYLL KALDKYWHED CLKCACCDCR LGEVGSTLYT KANLILCRRD YLRLFGTTGN CAACSKLIPA FEMVMRARDN VYHLDCFACQ LCNQRFCVGD KFFLKNNMIL CQMDYEEGQL NGTFESQVQ |
LIM domain only 1 (LMO1) is a protein-coding gene. LMO1 encodes a transcriptional regulator which contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains might play a part in protein interactions; hence the protein may regulate transcription by competitively binding to specific DNA-binding transcription factors.
LMO1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (1-156 a.a) and having a molecular mass of 20.2kDa.LMO1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LMO1: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD. |
| UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 11p15 Cellular Component: nucleus Molecular Function:zinc ion binding Biological Process: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P25800 |
| NCBI GenInfo Identifier: | 394025675 |
| NCBI Gene ID: | 4004 |
| NCBI Accession: | NP_001257357.1 |
| UniProt Secondary Accession: | P25800,Q4VBC5, Q8IXR0, E9PSF5, |
| UniProt Related Accession: | P25800 |
| Molecular Weight: | Calculated MW: 17kDaObserved MW: 14kDa |
| NCBI Full Name: | rhombotin-1 isoform b |
| NCBI Synonym Full Names: | LIM domain only 1 (rhombotin 1) |
| NCBI Official Symbol: | LMO1�� |
| NCBI Official Synonym Symbols: | TTG1; RBTN1; RHOM1�� |
| NCBI Protein Information: | rhombotin-1 |
| UniProt Protein Name: | Rhombotin-1 |
| UniProt Synonym Protein Names: | Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1 |
| Protein Family: | Rhombotin |
| UniProt Gene Name: | LMO1�� |
| UniProt Entry Name: | RBTN1_HUMAN |
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