Human LIN7B Recombinant Protein (RPPB3864)
- SKU:
- RPPB3864
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HAP6
Frequently bought together:
Description
| Product Name: | Human LIN7B Recombinant Protein |
| Product Code: | RPPB3864 |
| Size: | 10µg |
| Species: | Human |
| Target: | LIN7B |
| Synonyms: | LIN-7B, MALS-2, MALS2, VELI2, Protein lin-7 homolog B, Veli-2, hVeli2, Mammalian lin-seven protein 2, Vertebrate lin-7 homolog 2, UNQ3116/PRO10200. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LIN7B protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAALVEP LGLERDVSRA VELLERLQRS GELPPQKLQA LQRVLQSRFC SAIREVYEQL YDTLDITGSA EIRAHATAKA TVAAFTASEG HAHPRVVELP KTDEGLGFNI MGGKEQNSPI YISRVIPGGV ADRHGGLKRG DQLLSVNGVS VEGEQHEKAV ELLKAAQGSV KLVVRYTPRV LEEMEARFEK MRSARRRQQH QSYSSLESRG |
LIN7B (VELI2), is a member of the Velis family. Velis family contains minor synaptic proteins which interact with other proteins at the post-synaptic density (PSD) of neuronal synapses. Velis which contain the PDZ motif, participate in recruiting cell adhesion molecules, receptors, and channels. Lin7B protein is ubiquitously expressed with a high expression in the brain, liver, and testis. Lin7B localizes at the synaptic junctions in neurons, bind to CASK, which is a neurexin-binding protein highly concentrated in synapses, and Mint1, a binding partner with a vesicle trafficking protein.
LIN7B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 230 amino acids (1-207 a.a.) and having a molecular mass of 25.3kDa.LIN7B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LIN7B: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface. Belongs to the lin-7 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 19q13.3Cellular Component: postsynaptic membrane; neuron projection; tight junction; basolateral plasma membrane; postsynaptic density; synapse; intercellular junctionMolecular Function: protein domain specific bindingBiological Process: asymmetric protein localization; protein transport; exocytosis; neurotransmitter secretion; maintenance of epithelial cell polarity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9HAP6 |
| NCBI GenInfo Identifier: | 11545920 |
| NCBI Gene ID: | 64130 |
| NCBI Accession: | NP_071448.1 |
| UniProt Secondary Accession: | Q9HAP6 |
| UniProt Related Accession: | Q9HAP6 |
| Molecular Weight: | 15,620 Da |
| NCBI Full Name: | protein lin-7 homolog B |
| NCBI Synonym Full Names: | lin-7 homolog B (C. elegans) |
| NCBI Official Symbol: | LIN7B�� |
| NCBI Official Synonym Symbols: | MALS2; VELI2; LIN-7B; MALS-2�� |
| NCBI Protein Information: | protein lin-7 homolog B; hLin7B; hVeli2; mammalian lin-seven protein 2; veli-2; vertebrate lin-7 homolog 2 |
| UniProt Protein Name: | Protein lin-7 homolog B |
| UniProt Synonym Protein Names: | Mammalian lin-seven protein 2; MALS-2; Vertebrate lin-7 homolog 2; Veli-2; hVeli2 |
| Protein Family: | Protein |
| UniProt Gene Name: | LIN7B�� |
| UniProt Entry Name: | LIN7B_HUMAN |
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