Human LGALS7 Recombinant Protein (RPPB0285)
- SKU:
- RPPB0285
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P47929
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human LGALS7 Recombinant Protein |
| Product Code: | RPPB0285 |
| Size: | 20µg |
| Species: | Human |
| Target: | LGALS7 |
| Synonyms: | Galectin-7, Gal-7, HKL-14, PI7, p53-induced gene 1 protein, LGALS7, PIG1, LGALS7B, GAL7, LGALS7A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The Galectin-7 solution (1 mg/ml) 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH FNPRLDTSEV VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA VVGDAQYHHF RHRLPLARVR LVEVGGDVQL DSVRIF |
Galectins are a family of animal lectins with an affinity for beta-galactosides. This family has at least 14 identified members. Galectins share similarities in the CRD (the carbohydrate recognition domain). Galectins are synthesized as cytosolic proteins. Though localized principally in the cytoplasm and lacking a classical signal peptide, galectins can also be stimulated to secretion by non-classical pathways or alternatively targeted to the nucleus. Galectins are involved in modulating cell-cell and cell-matrix interactions. Human Galectin-7 belongs to the prototypical Galectins containing a single CRD, which is initially identified in human epidermis as a monomer. The Galectin-7 expression is induced by tumor suppressor protein p53 and associated with apoptosis. Galectin-7 is a pro-apoptotic protein which functions intracellularlly upstream of JNK activation and mitochondrial cytochrome c release. The correlation of Galectin-7 with the UV-induced apoptosis of keratinocytes presents a critical mechanism in the maintenance of epidermal homeostasis. Human Galectin-7 is localized in both nucleus and cytoplasm.
Galectin-7 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids (1-136 a.a.) and having a molecular mass of 17.2kDa. The Galectin-7 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LGALS7B: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. |
| UniProt Protein Details: | Protein type:Apoptosis; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: cytoplasm; extracellular space; nucleus Molecular Function:carbohydrate binding Biological Process: apoptosis; heterophilic cell adhesion |
| NCBI Summary: | The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P47929 |
| NCBI GenInfo Identifier: | 1346431 |
| NCBI Gene ID: | 653499 |
| NCBI Accession: | P47929.2 |
| UniProt Secondary Accession: | P47929,Q6IB87, |
| UniProt Related Accession: | P47929 |
| Molecular Weight: | 15,075 Da |
| NCBI Full Name: | Galectin-7 |
| NCBI Synonym Full Names: | lectin, galactoside binding soluble 7B |
| NCBI Official Symbol: | LGALS7B�� |
| NCBI Official Synonym Symbols: | PI7; GAL7; Gal-7; HKL-14; LGALS7�� |
| NCBI Protein Information: | galectin-7 |
| UniProt Protein Name: | Galectin-7 |
| UniProt Synonym Protein Names: | HKL-14; PI7; p53-induced gene 1 protein |
| Protein Family: | Galectin |
| UniProt Gene Name: | LGALS7�� |
| UniProt Entry Name: | LEG7_HUMAN |
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