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Human LGALS4 Recombinant Protein (RPPB0282)

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SKU:
RPPB0282
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P56470
Research Area:
Growth Factors & Cytokines
€469

Description

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Product Name:Human LGALS4 Recombinant Protein
Product Code:RPPB0282
Size:25µg
Species:Human
Target:LGALS4
Synonyms:Galectin-4, Gal-4, Lactose-binding lectin 4, L-36 lactose-binding protein, L36LBP, Antigen NY-CO-27, LGALS4, lectin galactoside-binding soluble 4, GAL4.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The LGALS4 protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR LSAFQRVDTL EIQGDVTLSY VQI

Galectin-4 is a member of the subfamily of galectins composed of two carbohydrate recognition domains having similar peptide chains. The galectins are a family of beta-galactoside-binding proteins having a role in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic responses. LGALS4 expression is limited to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. LGALS4 binds as an endogenous ligand to glycosphingolipids having 3-O-sulfated Gal residues and bind as well to cholesterol-3-sulfate. LGALS4 takes part in cell adhesion. LGALS4 plays a role in crosslinking the lateral cell membranes of the surface-lining epithelial cells, thus supporting epithelial integrity against mechanical stress exerted by the bowel lume. LGALS4 is in charge of intestinal inflammation via selective regulation of peripheral and mucosal T-cell cell cycle, in addition to cell death by apoptosis of T-cells by a pathway independent of the activation of caspases. LGALS4 blockade decreases TNF-alpha inhibitor induced T-cell death. LGALS4 decreases pro-inflammatory cytokine secretion including IL-6 & IL-17.

Galectin-4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (1-323 a.a.) and having a molecular mass of 38.1kDa.Galectin-4 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:galectin-4: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytosol; plasma membrane

Biological Process: cell adhesion

NCBI Summary:The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
UniProt Code:P56470
NCBI GenInfo Identifier:3024079
NCBI Gene ID:3960
NCBI Accession:P56470.1
UniProt Related Accession:P56470
Molecular Weight:35,941 Da
NCBI Full Name:Galectin-4
NCBI Synonym Full Names:galectin 4
NCBI Official Symbol:LGALS4��
NCBI Official Synonym Symbols:GAL4; L36LBP��
NCBI Protein Information:galectin-4
UniProt Protein Name:Galectin-4
UniProt Synonym Protein Names:Antigen NY-CO-27; L-36 lactose-binding protein; L36LBP; Lactose-binding lectin 4
Protein Family:Galectin
UniProt Gene Name:LGALS4��
UniProt Entry Name:LEG4_HUMAN

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