Human LAMTOR4 Recombinant Protein (RPPB3842)
- SKU:
- RPPB3842
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q0VGL1
Description
| Product Name: | Human LAMTOR4 Recombinant Protein |
| Product Code: | RPPB3842 |
| Size: | 10µg |
| Species: | Human |
| Target: | LAMTOR4 |
| Synonyms: | Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator4, C7orf59, Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4, Chromosome7 Open Reading Frame 59, Ragulator Complex Protein LAMTOR4, UPF0539 ProteinC7orf59, LAMTOR4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | LAMTOR4 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTSALTQ GLERIPDQLG YLVLSEGAVL ASSGDLENDE QAASAISELVSTACGFRLHR GMNVPFKRLS VVFGEHTLLV TVSGQRVFVV KRQNRGREPI DV |
| UniProt Code: | Q0VGL1 |
LAMTOR4 is implicated in amino acid sensing and activation of mTORC1,which is a signaling complex promoting cell growth in response to growthfactors, energy levels, and amino acids. LAMTOR4 is activated by amino acids viaa mechanism which involves the lysosomal V-ATPase, the Ragulator functions as aguanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulatorand Rag GTPases both function as a scaffold recruiting mTORC1 to lysosomeswhere it is sequentially activated.
LAMTOR4 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 122 amino acids (1-99 a.a) andhaving a molecular mass of 13.1kDa.LAMTOR4 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
