Human KLRC2 Recombinant Protein (RPPB3803)
- SKU:
- RPPB3803
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P26717
Description
| Product Name: | Human KLRC2 Recombinant Protein |
| Product Code: | RPPB3803 |
| Size: | 10µg |
| Species: | Human |
| Target: | KLRC2 |
| Synonyms: | Killer cell lectin-like receptor subfamily C member 2, NKG2-C type II integral membrane protein, NKG2-C-activating NK receptor, CD159 antigen-like family member C, NK cell receptor C, NKG2C, CD159c. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The KLRC2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMIPFLEQ NNFSPNTRTQ KARHCGHCPE EWITYSNSCY YIGKERRTWE ESLLACTSKN SSLLSIDNEE EMKFLASILP SSWIGVFRNS SHHPWVTING LAFKHKIKDS DNAELNCAVL QVNRLKSAQC GSSMIYHCKH KL |
KLRC2 has a part as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The group, designated KLRC (NKG2) are expressed mainly in natural killer (NK) cells and encodes a family of transmembrane proteins categorized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is situated inside the NK complex, a region which holds a few C-type lectin genes specially expressed on NK cells. KLRC2 alternative splice variants are known but their full-length nature is yet to be determined.
KLRC2 Human Recombinant produced in E. coli is a single polypeptide chain containing 162 amino acids (94-231) and having a molecular mass of 18.4 kDa.KLRC2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KLRC2: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: integral to plasma membrane; plasma membrane; receptor complexMolecular Function: protein binding; transmembrane receptor activityBiological Process: cellular defense response; innate immune response; natural killer cell mediated immunity; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26717 |
| NCBI GenInfo Identifier: | 20141529 |
| NCBI Gene ID: | 3822 |
| NCBI Accession: | P26717.2 |
| UniProt Secondary Accession: | P26717,O43802, Q52M74, Q9NR42 |
| UniProt Related Accession: | P26717 |
| Molecular Weight: | 26,072 Da |
| NCBI Full Name: | NKG2-C type II integral membrane protein |
| NCBI Synonym Full Names: | killer cell lectin like receptor C2 |
| NCBI Official Symbol: | KLRC2�� |
| NCBI Official Synonym Symbols: | NKG2C; CD159c; NKG2-C�� |
| NCBI Protein Information: | NKG2-C type II integral membrane protein |
| UniProt Protein Name: | NKG2-C type II integral membrane protein |
| UniProt Synonym Protein Names: | CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor; CD_antigen: CD159c |
| Protein Family: | NKG2-C type II integral membrane protein |
| UniProt Gene Name: | KLRC2�� |
| UniProt Entry Name: | NKG2C_HUMAN |
