Human KLK2 Recombinant Protein (RPPB1860)
- SKU:
- RPPB1860
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20151
- Research Area:
- Enzymes
Description
| Product Name: | Human KLK2 Recombinant Protein |
| Product Code: | RPPB1860 |
| Size: | 20µg |
| Species: | Human |
| Target: | KLK2 |
| Synonyms: | hK2, KLK2A2, Kallikrein-2, Glandular kallikrein-1, hGK-1, issue kallikrein-2, KLK2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The KLK2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSIVGGWEC EKHSQPWQVA VYSHGWAHCG GVLVHPQWVL TAAHCLKKNS QVWLGRHNLF EPEDTGQRVP VSHSFPHPLY NMSLLKHQSL RPDEDSSHDL MLLRLSEPAK ITDVVKVLGL PTQEPALGTT CYASGWGSIE PEEFLRPRSL QCVSLHLLSN DMCARAYSEK VTEFMLCAGL WTGGKDTCGG DSGGPLVCNG VLQGITSWGP EPCALPEKPA VYTKVVHYRK WIKDTIAANP |
KLK2 is a part of the grandular kallikrein protein family whose Members are engaged in a diverse array of biological functions. Kallikreins are a subgroup of serine proteases which are clustered on chromosome 19. KLK2 is a highly active trypsin-like serine protease which selectively cleaves at arginine remains. KLK2 is mostly expressed in prostatic tissue and is accountable for cleaving pro-prostate-specific antigen into its enzymatically active form. KLK2 is greatly expressed in prostate tumor cells and may possibly be a prognostic maker for prostate cancer risk.
KLK2 Human Recombinant produced in E. coli is a single polypeptide chain containing 260 amino acids (25-261) and having a molecular mass of 28.5kDa. KLK2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.21.35; Protease Chromosomal Location of Human Ortholog: 19q13.41 Cellular Component: extracellular region Molecular Function:serine-type endopeptidase activity Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis |
| NCBI Summary: | This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P20151 |
| NCBI GenInfo Identifier: | 125174 |
| NCBI Gene ID: | 3817 |
| NCBI Accession: | P20151.1 |
| UniProt Secondary Accession: | P20151,Q15946, Q9UJZ9, B4DU93, B4DUB0, F5H8L3, |
| UniProt Related Accession: | P20151 |
| Molecular Weight: | 261 |
| NCBI Full Name: | Kallikrein-2 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 2 |
| NCBI Official Symbol: | KLK2�� |
| NCBI Official Synonym Symbols: | hK2; hGK-1; KLK2A2�� |
| NCBI Protein Information: | kallikrein-2; tissue kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; kallikrein 2, prostatic |
| UniProt Protein Name: | Kallikrein-2 |
| UniProt Synonym Protein Names: | Glandular kallikrein-1; hGK-1; Tissue kallikrein-2 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK2�� |
| UniProt Entry Name: | KLK2_HUMAN |
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