Human KIAA0101 Recombinant Protein (RPPB3782)
- SKU:
- RPPB3782
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15004
Description
| Product Name: | Human KIAA0101 Recombinant Protein |
| Product Code: | RPPB3782 |
| Size: | 10µg |
| Species: | Human |
| Target: | KIAA0101 |
| Synonyms: | KIAA0101, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, p15(PAF), p15/PAF, p15PAF, PAF, PAF15, PCNA-associated factor, Hepatitis C virus NS5A-transactivated protein 9, HCV NS5A-transactivated protein 9, Overexpressed in anaplastic thyroid carcinoma 1, PCNA-associated factor of 15 kDa. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The KIAA0101 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMVRTKAD SVPGTYRKVV AARAPRKVLG SSTSATNSTS VSSRKAENKY AGGNPVCVRP TPKWQKGIGE FFRLSPKDSE KENQIPEEAG SSGLGKAKRK ACPLQPDHTN DEKE |
KIAA0101 is a PCNA-binding protein which performs as a regulator of DNA repair all through DNA replication. Subsequent to DNA mutilation, the collaboration with PCNA is interrupted, enabling the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, assisting the bypass of replication-fork-blocking lesions. Additionally, KIAA0101 performs as a controller of centrosome number.
KIAA0101 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 134 amino acids (1-111) and having a molecular mass of 14.4 kDa.KIAA0101 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PAF: May be involved in protection of cells from UV-induced cell death. |
| UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: centrosome; nucleoplasm; nucleus; perinuclear region of cytoplasm Molecular Function:chromatin binding; protein binding Biological Process: bypass DNA synthesis; centrosome cycle; DNA replication; regulation of cell cycle; response to DNA damage stimulus; response to UV |
| UniProt Code: | Q15004 |
| NCBI GenInfo Identifier: | 3183216 |
| NCBI Gene ID: | 9768 |
| NCBI Accession: | Q15004.1 |
| UniProt Secondary Accession: | Q15004,A6NNU5, A8K3Y3, G9G694, G9G696, |
| UniProt Related Accession: | Q15004 |
| Molecular Weight: | 12kDa |
| NCBI Full Name: | PCNA-associated factor |
| NCBI Synonym Full Names: | PCNA clamp associated factor |
| NCBI Official Symbol: | PCLAF�� |
| NCBI Official Synonym Symbols: | L5; PAF; OEATC; PAF15; OEATC1; p15PAF; NS5ATP9; OEATC-1; p15/PAF; KIAA0101; p15(PAF)�� |
| NCBI Protein Information: | PCNA-associated factor |
| UniProt Protein Name: | PCNA-associated factor |
| UniProt Synonym Protein Names: | Hepatitis C virus NS5A-transactivated protein 9; HCV NS5A-transactivated protein 9; Overexpressed in anaplastic thyroid carcinoma 1; OEATC-1; PCNA-associated factor of 15 kDa; PAF15; p15PAF; PCNA-clamp-associated factor |
| UniProt Gene Name: | PCLAF�� |
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