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Human JSRP1 Recombinant Protein (RPPB3772)

SKU:
RPPB3772
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96MG2
€309
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Description

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Product Name:Human JSRP1 Recombinant Protein
Product Code:RPPB3772
Size:10µg
Species:Human
Target:JSRP1
Synonyms:Junctional Sarcoplasmic Reticulum Protein 1, Homolog of Mouse Skeletal Muscle Sarcoplasmic Reticulum Protein JP-45, Junctional-Face Membrane Protein Of 45 KDa Homolog, JP45, 2310032K21Rik, Skeletal Muscle Sarcoplasmic Reticulum Protein JP-45.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The JSRP1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSMTTRA WEELDGGLGS CQALEDHSAL AETQEDRASA TPRLADSGSV PHDSQVAEGP SVDTRPKKME KEPAARGTPG TGKERLKAGA SPRSVPARKK AQTAPPLQPP PPPPALSEEL PWGDLSLNKC LVLASLVALL GSAFQLCRDA VPGEAALQAR VPEPWVPPSS APREPSSPLP KFEAQAPPSA PPAPRAEAEV RPKIPGSREA AENDEEEPGE ATGEAVREDR VTLADRGPKE RPRREGKPRK EKPRKEERPK KERPRKEERP RAAREPREAL PQRWESREGG HRPWARDSRD AEPRKKQAWV SPRRPDEEQR PGSRQKLRAG KGRD

JSRP1 takes part in excitation-contraction connection at the sarcoplasmic reticulum. JSRP1 is able to cooperate with CACNA1S, CACNB1 and calsequestrin to assist in regulating calcium influx and efflux in skeletal muscle.

JSRP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 354 amino acids (1-331) and having a molecular mass of 38.0kDa.JSRP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:JSRP1: May function as a regulator of the voltage-sensitive calcium channel CACNA1S. May regulate CACNA1S membrane targeting and activity. May function in excitation/contraction coupling in muscle cells.Chromosomal Location of Human Ortholog: 19p13.3Cellular Component: sarcoplasmic reticulum membraneBiological Process: skeletal muscle contraction
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. [provided by RefSeq, Jul 2012]
UniProt Code:Q96MG2
NCBI GenInfo Identifier:21389423
NCBI Gene ID:126306
NCBI Accession:NP_653217.1
UniProt Secondary Accession:Q96MG2
UniProt Related Accession:Q96MG2
Molecular Weight:36,319 Da
NCBI Full Name:junctional sarcoplasmic reticulum protein 1
NCBI Synonym Full Names:junctional sarcoplasmic reticulum protein 1
NCBI Official Symbol:JSRP1��
NCBI Official Synonym Symbols:JP45; JP-45��
NCBI Protein Information:junctional sarcoplasmic reticulum protein 1; 2310032K21Rik; junctional-face membrane protein of 45 kDa homolog; skeletal muscle sarcoplasmic reticulum protein JP-45; homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45
UniProt Protein Name:Junctional sarcoplasmic reticulum protein 1
UniProt Synonym Protein Names:Junctional-face membrane protein of 45 kDa homolog; JP-45
Protein Family:Junctional sarcoplasmic reticulum protein
UniProt Gene Name:JSRP1��
UniProt Entry Name:JSPR1_HUMAN

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