Human IRF 5 Recombinant Protein (RPPB0414)
- SKU:
- RPPB0414
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13568
- Research Area:
- Cytokines
Description
| Product Name: | Human IRF 5 Recombinant Protein |
| Product Code: | RPPB0414 |
| Size: | 10µg |
| Species: | Human |
| Target: | IRF 5 |
| Synonyms: | IFN Regulatory Factor 5, IRF-5, SLEB10, IBD14. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | IRF5 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30%glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSPPTL QPPTLQPPVV LGPPAPDPSP LAPPPGNPAG FRELLSEVLEPGPLPASLPP AGEQLLPDLL I |
IFN Regulatory Factor-5, also known as IRF5 belongs to the IFN regulatory factor (IRF) family, a group of transcription factors with various functions, including virus-mediated activation of IFN, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, IRF5 is implicated in the induction of IFNs IFNA and INFB and inflammatory cytokines upon virus infection. IRF5 is activated by TLR7 or TLR8 signaling.
IRF5 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 101 amino acids (176-240a.a) andhaving a molecular mass of 10.7kDa.IRF5 is fused to a 36 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 7q32 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: transcription, DNA-dependent; positive regulation of apoptosis; response to muramyl dipeptide; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; response to peptidoglycan; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of interferon-alpha production Disease: Systemic Lupus Erythematosus, Susceptibility To, 10; Inflammatory Bowel Disease 14 |
| NCBI Summary: | This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q13568 |
| NCBI GenInfo Identifier: | 20178305 |
| NCBI Gene ID: | 3663 |
| NCBI Accession: | Q13568.2 |
| UniProt Secondary Accession: | Q13568,Q1A7B4, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0 A4D1J8, A8DUA8, A8DUA9, E7EQ16, E7EW54, |
| UniProt Related Accession: | Q13568 |
| Molecular Weight: | 498 |
| NCBI Full Name: | Interferon regulatory factor 5 |
| NCBI Synonym Full Names: | interferon regulatory factor 5 |
| NCBI Official Symbol: | IRF5�� |
| NCBI Official Synonym Symbols: | SLEB10�� |
| NCBI Protein Information: | interferon regulatory factor 5 |
| UniProt Protein Name: | Interferon regulatory factor 5 |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | IRF5�� |
| UniProt Entry Name: | IRF5_HUMAN |
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