Human IMPA1 Recombinant Protein (RPPB1848)
- SKU:
- RPPB1848
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P29218
- Research Area:
- Enzymes
Description
| Product Name: | Human IMPA1 Recombinant Protein |
| Product Code: | RPPB1848 |
| Size: | 20µg |
| Species: | Human |
| Target: | IMPA1 |
| Synonyms: | Inositol monophosphatase 1, IMP 1, IMPase 1, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1, IMPA1, IMPA, IMP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IMPA1 solution (1mg/ml) contains 20mM Tris-HCl Buffer (pH 8.0) and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED |
Inositol monophosphatase1 (IMPA1) is responsible for the provision of inositol essential for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 has a central role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. IMPA1 has been recognized as the pharmacological target for lithium action in the brain. The IMPA1 enzyme has a magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and ensuing depletion of inositol for phosphatidylinositol synthesis may perhaps explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder.
IMPA1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 297 amino acids (1-277 a.a.) and having a molecular mass of 32.3kDa. The IMPA1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IMPA1: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.94; EC 3.1.3.25 Chromosomal Location of Human Ortholog: 8q21.13-q21.3 Cellular Component: cytoplasm; cytosol Molecular Function:identical protein binding; protein homodimerization activity; manganese ion binding; inositol-1(or 4)-monophosphatase activity; magnesium ion binding; lithium ion binding Biological Process: inositol phosphate metabolic process; phosphoinositide phosphorylation; inositol phosphate dephosphorylation; inositol biosynthetic process; phosphatidylinositol biosynthetic process; signal transduction; phosphate metabolic process |
| NCBI Summary: | This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P29218 |
| NCBI GenInfo Identifier: | 127717 |
| NCBI Gene ID: | 3612 |
| NCBI Accession: | P29218.1 |
| UniProt Secondary Accession: | P29218,Q9UK71, B2R733, B4DLN3, B7Z6Q4, J3KQT7, |
| UniProt Related Accession: | P29218 |
| Molecular Weight: | 277 |
| NCBI Full Name: | Inositol monophosphatase 1 |
| NCBI Synonym Full Names: | inositol(myo)-1(or 4)-monophosphatase 1 |
| NCBI Official Symbol: | IMPA1�� |
| NCBI Official Synonym Symbols: | IMP; IMPA�� |
| NCBI Protein Information: | inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; D-galactose 1-phosphate phosphatase; lithium-sensitive myo-inositol monophosphatase A1 |
| UniProt Protein Name: | Inositol monophosphatase 1 |
| UniProt Synonym Protein Names: | D-galactose 1-phosphate phosphatase |
| Protein Family: | Inositol monophosphatase |
| UniProt Gene Name: | IMPA1�� |
| UniProt Entry Name: | IMPA1_HUMAN |
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