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Human IL34 Recombinant Protein (RPPB0669)

SKU:
RPPB0669
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6ZMJ4
Research Area:
Cytokines
€309
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Description

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Product Name:Human IL34 Recombinant Protein
Product Code:RPPB0669
Size:10µg
Species:Human
Target:IL34
Synonyms:Interleukin 34, C16orf77, MGC34647, IL34.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The IL34 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMNE PLEMWPLTQN EECTVTGFLR DKLQYRSRLQ YMKHYFPINY KISVPYEGVF RIANVTRLQR AQVSERELRY LWVLVSLSAT ESVQDVLLEG HPSWKYLQEV QTLLLNVQQG LTDVEVSPKV ESVLSLLNAP GPNLKLVRPK ALLDNCFRVM ELLYCSCCKQ SSVLNWQDCE VPSPQSCSPE PSLQYAATQL YPPPPWSPSS PPHSTGSVRP VRAQGEGLLP

Interleukin 34 (IL34) is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor and is a part of a group of cytokines called interleukins. IL34 increases growth or survival of immune cells known as monocytes. IL34 protein obtains its activity by binding the Colony stimulating factor 1 receptor. Interleukin 34 has also a potential part in viral infection, the adaptive immune response and bone marrow cell proliferation. Furthermore, IL34 plays an important role in innate immunity and in inflammatory processes.

IL34 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 260 amino acids (21-242 a.a) and having a molecular mass of 29.6kDa. IL34 is fused to a 38 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine; Cell cycle regulation; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular region; extracellular space

Molecular Function:macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of cell proliferation; positive regulation of macrophage differentiation; positive regulation of monocyte differentiation; positive regulation of protein amino acid phosphorylation

NCBI Summary:Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
UniProt Code:Q6ZMJ4
NCBI GenInfo Identifier:74710540
NCBI Gene ID:146433
NCBI Accession:Q6ZMJ4.1
UniProt Secondary Accession:Q6ZMJ4,Q8N6L2, B2RC28, B2Z4A8, B2ZC70,
UniProt Related Accession:Q6ZMJ4
Molecular Weight:27,354 Da
NCBI Full Name:Interleukin-34
NCBI Synonym Full Names:interleukin 34
NCBI Official Symbol:IL34��
NCBI Official Synonym Symbols:IL-34; C16orf77��
NCBI Protein Information:interleukin-34
UniProt Protein Name:Interleukin-34
Protein Family:Interleukin
UniProt Gene Name:IL34��
UniProt Entry Name:IL34_HUMAN

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