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Human IL18BP Recombinant Protein (RPPB0622)

SKU:
RPPB0622
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95998
Research Area:
Cytokines
$371
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Description

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Product Name:Human IL18BP Recombinant Protein
Product Code:RPPB0622
Size:20µg
Species:Human
Target:IL18BP
Synonyms:Interleukin 18 Binding Protein, MC51L-53L-54L HomologGene Product, Tadekinig-Alfa, IL-18BP, IL18BPa, Interleukin-18-binding protein, Tadekinig-alfa.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:IL18BP protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVPLNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTNFSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSHSSPQQQG

Interleukin-18 Binding Protein (IL18BP) serves as an inhibitor of the proinflammatory cytokine, IL18. IL18BP binds IL18, inhibits the binding of IL18 to its receptor, and consequently inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. The IL18BP protein is constitutively expressed and secreted in mononuclear cells. Elevated levels of IL18BP protein are detected in the intestinal tissues of patients with Crohn's disease.

IL18BP Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 187 amino acids (31-194 a.a) andhaving a molecular mass of 20kDa.IL18BP is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; extracellular region

Molecular Function:receptor antagonist activity; interleukin-18 binding

Biological Process: T-helper 1 type immune response; response to lipopolysaccharide

NCBI Summary:The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
UniProt Code:O95998
NCBI GenInfo Identifier:251757286
NCBI Gene ID:10068
NCBI Accession:O95998.2
UniProt Secondary Accession:O95998,O95993, O96027, Q9NZA9, Q9UBR7, B3KUZ0, B7WPK4
UniProt Related Accession:O95998
Molecular Weight:17,478 Da
NCBI Full Name:Interleukin-18-binding protein
NCBI Synonym Full Names:interleukin 18 binding protein
NCBI Official Symbol:IL18BP��
NCBI Official Synonym Symbols:IL18BPa��
NCBI Protein Information:interleukin-18-binding protein; IL-18BP; MC51L-53L-54L homolog gene product; tadekinig-alfa
UniProt Protein Name:Interleukin-18-binding protein
UniProt Synonym Protein Names:Tadekinig-alfa
Protein Family:Interleukin-18-binding protein
UniProt Gene Name:IL18BP��
UniProt Entry Name:I18BP_HUMAN

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