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Human IL17D Recombinant Protein (RPPB0602)

SKU:
RPPB0602
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8TAD2
Research Area:
Cytokines
€309
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Description

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Product Name:Human IL17D Recombinant Protein
Product Code:RPPB0602
Size:25µg
Species:Human
Target:IL17D
Synonyms:Interleukin 17D, Interleukin 27, IL-17D, IL-27, IL27, Interleukin-17D, Interleukin-27, IL17D.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered solution in Acetonitrile and TFA.
Solubility:It is recommended to reconstitute the lyophilized IL-17D in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IL17D although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-17D should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by SDS-PAGE.
Amino Acid Sequence:APRAGRRPAR PRGCADRPEE LLEQLYGRLA AGVLSAFHHT LQLGPREQAR NASCPAGGRP ADRRFRPPTN LRSVSPWAYR ISYDPARYPR YLPEAYCLCR GCLTGLFGEE DVRFRSAPVY MPTVVLRRTP ACAGGRSVYT EAYVTIPVGC TCVPEPEKDA DSINSSIDKQ GAKLLLGPND APAGP
Biological Activity:Immobilized rHuIL-17D binds to rHuIL-17BR with EC50 less than 2�g/ml.

IL17D modulates immune responses indirectly by stimulating the production of myeloid growth factors and chemokines, as well as suppressing the proliferation of myeloid progenitors. IL17D is expressed in the skeletal muscle, heart, adipose tissue, lung, pancreas, and nervous system. Among IL-17 family members, IL17D is most closely related to IL17B, sharing 27% aa sequence identity. The treatment of endothelial cells with IL17D cytokine stimulates the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by IL17D cytokine is NF-kappa B-dependent.

Interleukin-17D Human Recombinant (18-202) produced in E.Coli is a non-glycosylated disulfide-linked homodimer containing 2 polypeptide chains of 185 amino acids each and having a molecular mass of 40kDa.The IL-17D is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL17D: Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. Belongs to the IL-17 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 13q11

Cellular Component: extracellular space

Molecular Function:cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding

Biological Process: cell surface receptor linked signal transduction; inflammatory response

NCBI Summary:The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TAD2
NCBI GenInfo Identifier:46576614
NCBI Gene ID:53342
NCBI Accession:Q8TAD2.1
UniProt Secondary Accession:Q8TAD2,B1AM69,
UniProt Related Accession:Q8TAD2
Molecular Weight:21,893 Da
NCBI Full Name:Interleukin-17D
NCBI Synonym Full Names:interleukin 17D
NCBI Official Symbol:IL17D��
NCBI Official Synonym Symbols:IL-17D��
NCBI Protein Information:interleukin-17D
UniProt Protein Name:Interleukin-17D
UniProt Synonym Protein Names:Interleukin-27
Protein Family:Interleukin
UniProt Gene Name:IL17D��
UniProt Entry Name:IL17D_HUMAN

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