Human IL12RB1 Recombinant Protein (RPPB0572)
- SKU:
- RPPB0572
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P42701
- Research Area:
- Cytokines
Description
| Product Name: | Human IL12RB1 Recombinant Protein |
| Product Code: | RPPB0572 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL12RB1 |
| Synonyms: | Interleukin 12 Receptor Beta 1, IL-12 Receptor BetaComponent, IL-12 Receptor Subunit Beta-1, IL-12R Subunit Beta-1, IL12RB,Interleukin-12 Receptor Subunit Beta-1, Interleukin-12 Receptor Beta-1 Chain,Cluster Of Differentiation 212, CD212 Antigen, IL-12R-Beta-1, IL-12R-BETA1,IL-12RB1, CD212, IMD30, IL12R. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | IL12RB1 protein solution (0.25mg/ml) containing 20mM TRIS8.0 buffer and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSMEPLVTWVVPLLFLFLL SRQGAACRTS ECCFQDPPYP DADSGSASGP RDLRCYRISS DRYECSWQYE GPTAGVSHFLRCCLSSGRCC YFAAGSATRL QFSDQAGVSV LYTVTLWVES WARNQTEKSP EVTLQLYNSV KYEPPLGDIKVSKLAGQLRM EWETPDNQVG AEVQFRHRTP SSPWKLGDCG PQDDDTESCL CPLEMNVAQE FQLRRRQLGSQGSSWSKWSS PVCVPPENPP QPQVRFSVEQ LGQDGRRRLT LKEQPTQLEL PEGCQGLAPG TEVTYRLQLHMLSCPCKAKA TRTLHLGKMP YLSGAAYNVA VISSNQFGPG LNQTWHIPAD THTEPVALNI SVGTNGTTMYWPARAQSMTY CIEWQPVGQD GGLATCSLTA PQDPDPAGMA TYSWSRESGA MGQEKCYYIT IFASAHPEKL TLWSTVLSTYHFGGNASAAG TPHHVSVKNH SLDSVSVDWA PSLLSTCPGV LKEYVVRCRD EDSKQVSEHP VQPTETQVTLSGLRAGVAYT VQVRADTAWL RGVWSQPQRF SIEVQVSD |
IL-12 is a heterodimeric cytokine that stimulates the production of IFN gamma from T-cells and natural killer cells, and also induces differentiation of Th1 helper cells. It is an initiator of cell-mediated immunity.
IL12RB1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 568 amino acids (1-545 a.a) andhaving a molecular mass of 62.6kDa. IL12RB1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL12RB1: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type I cytokine receptor family. Type 2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: external side of plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-12 receptor activity; interleukin-23 receptor activity; interleukin-23 binding; interleukin-12 receptor binding Biological Process: positive regulation of memory T cell differentiation; positive regulation of interferon-gamma production; peptidyl-tyrosine phosphorylation; positive regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; positive regulation of activated T cell proliferation; signal transduction; positive regulation of defense response to virus by host Disease: Immunodeficiency 30 |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Code: | P42701 |
| NCBI GenInfo Identifier: | 1170462 |
| NCBI Gene ID: | 3594 |
| NCBI Accession: | P42701.1 |
| UniProt Secondary Accession: | P42701,Q8N6Q7, A8K308, B2RPF1, B7ZKK3, |
| UniProt Related Accession: | P42701 |
| Molecular Weight: | 662 |
| NCBI Full Name: | Interleukin-12 receptor subunit beta-1 |
| NCBI Synonym Full Names: | interleukin 12 receptor, beta 1 |
| NCBI Official Symbol: | IL12RB1�� |
| NCBI Official Synonym Symbols: | CD212; IMD30; IL12RB; IL-12R-BETA1�� |
| NCBI Protein Information: | interleukin-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12 receptor beta component; IL-12 receptor subunit beta-1; cluster of differentiation 212; interleukin-12 receptor beta-1 chain |
| UniProt Protein Name: | Interleukin-12 receptor subunit beta-1 |
| UniProt Synonym Protein Names: | IL-12 receptor beta component; CD_antigen: CD212 |
| Protein Family: | Interleukin-12 receptor |
| UniProt Gene Name: | IL12RB1�� |
| UniProt Entry Name: | I12R1_HUMAN |
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