Human IL-9 Recombinant Protein (RPPB0548)
- SKU:
- RPPB0548
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P15248
- Research Area:
- Cytokines
Description
| Product Name: | Human IL-9 Recombinant Protein |
| Product Code: | RPPB0548 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL-9 |
| Synonyms: | Interleukin 9, Protein Il9, Il9, HP40, Cytokine P40, T-cell growth factor P40 |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IL-9 �solution (0.5mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QGCPTLAGIL DINFLINKMQ EDPASKCHCS ANVTSCLCLG IPSDNCTRPC FSERLSQMTNTTMQTRYPLI FSRVKKSVEV LKNNKCPYFS CEQPCNQTTA GNALTFLKSL LEIFQKEKMR GMRGKIHHHH HH |
| Biological Activity: | Determined by cell proliferation assay using MO7e human megakaryocytic leukemic cells. ED50 range for this effect is ? 0.3 ng/ml. |
Interleukin-9 is a protein that acts as one of the regulators of hematopoiesis. IL-9 is an enhancer of cells and megakaryoblastic leukemic cells� growth. Among this protein�s producers we can find cells like mast cells, Treg, NKT cells, Th17, Th2, ILC2, and Th9 cells in various amounts. Th9 are the primary CD4 cells (T cells) that IL-9 is produced in.
IL-9 Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 132 amino acids (19-144 aa) and having a molecular mass of 14.9kDa.IL-9 is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL9: Supports IL-2 independent and IL-4 independent growth of helper T-cells. Belongs to the IL-7/IL-9 family. |
| UniProt Protein Details: | Protein type:Secreted; Cytokine; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: extracellular space Molecular Function:growth factor activity; interleukin-9 receptor binding; cytokine activity Biological Process: positive regulation of cell proliferation; immune response; inflammatory response; positive regulation of cell growth; positive regulation of interleukin-5 biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15248 |
| NCBI GenInfo Identifier: | 124362 |
| NCBI Gene ID: | 3578 |
| NCBI Accession: | P15248.1 |
| UniProt Related Accession: | P15248 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | Interleukin-9 |
| NCBI Synonym Full Names: | interleukin 9 |
| NCBI Official Symbol: | IL9�� |
| NCBI Official Synonym Symbols: | P40; HP40; IL-9�� |
| NCBI Protein Information: | interleukin-9; cytokine P40; p40 cytokine; T-cell growth factor p40; p40 T-cell and mast cell growth factor; homolog of mouse T cell and mast cell growth factor 40 |
| UniProt Protein Name: | Interleukin-9 |
| UniProt Synonym Protein Names: | Cytokine P40; T-cell growth factor P40 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL9�� |
| UniProt Entry Name: | IL9_HUMAN |
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