Human IL 9 Recombinant Protein (RPPB0546)
- SKU:
- RPPB0546
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P15248
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 9 Recombinant Protein |
| Product Code: | RPPB0546 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL 9 |
| Synonyms: | P40, HP40, T-cell growth factor p40, IL-9, P40 cytokine. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | IL-9 protein was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin-9 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-9 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL9 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MQGCPTLAGI LDINFLINKM QEDPASKCHC SANVTSCLCL GIPSDNCTRP CFSERLSQMT NTTMQTRYPL IFSRVKKSVE VLKNNKCPYF SCEQPCNQTT AGNALTFLKS LLEIFQKEKM RGMRGKI |
| Biological Activity: | The ED50 as determined by the dose-dependent stimulation of human MO7e cells is less than 0.2 ng/ml, corresponding to a Specific Activity of >5.0�106 IU/mg. |
Factor that is thought to be a regulator of hematopoiesis. It has been shown to enhance the growth of human mast cells and megakaryoblastic leukemic cells as well as murine helper t-cell clones. IL-9 is a glycoprotein with a molecular weight of 32-39 that is derived from T-cells, and maps to human chromosome 5.
Interleukin-9 Human Recombinant produced in E.Coli is a single, non-glycosylated single polypeptide chain containing 127 amino acids and having a molecular mass of 14,004 Dalton. The IL-9 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL9: Supports IL-2 independent and IL-4 independent growth of helper T-cells. Belongs to the IL-7/IL-9 family. |
| UniProt Protein Details: | Protein type:Secreted; Cytokine; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: extracellular space Molecular Function:growth factor activity; interleukin-9 receptor binding; cytokine activity Biological Process: positive regulation of cell proliferation; immune response; inflammatory response; positive regulation of cell growth; positive regulation of interleukin-5 biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15248 |
| NCBI GenInfo Identifier: | 124362 |
| NCBI Gene ID: | 3578 |
| NCBI Accession: | P15248.1 |
| UniProt Related Accession: | P15248 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | Interleukin-9 |
| NCBI Synonym Full Names: | interleukin 9 |
| NCBI Official Symbol: | IL9�� |
| NCBI Official Synonym Symbols: | P40; HP40; IL-9�� |
| NCBI Protein Information: | interleukin-9; cytokine P40; p40 cytokine; T-cell growth factor p40; p40 T-cell and mast cell growth factor; homolog of mouse T cell and mast cell growth factor 40 |
| UniProt Protein Name: | Interleukin-9 |
| UniProt Synonym Protein Names: | Cytokine P40; T-cell growth factor P40 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL9�� |
| UniProt Entry Name: | IL9_HUMAN |
