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Human IL-5 Polyclonal Antibody (CAB21170)

SKU:
CAB21170
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Applications:
WB
Isotype:
IgG
Host Species:
Rabbit
$167 - $503
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Description

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Human IL-5 Polyclonal Antibody (CAB21170)

The Human IL-5 Polyclonal Antibody (PAB) is a valuable research tool for studying IL-5, a cytokine involved in the regulation of immune responses, particularly in the context of allergic inflammation and asthma. This antibody, developed using rabbit immunization, exhibits high reactivity with human samples and is validated for use in Western blot assays.IL-5 plays a crucial role in promoting the growth and activation of eosinophils, a type of white blood cell involved in allergic reactions and asthma pathophysiology. By targeting IL-5, researchers can better understand its role in immune regulation and potentially develop novel therapeutic approaches for conditions characterized by eosinophilic inflammation.

The Human IL-5 Polyclonal Antibody is a versatile tool for investigating IL-5 expression and function in various cell types, making it an ideal choice for studies in immunology, respiratory diseases, and allergy research. Its specificity and sensitivity make it a reliable reagent for detecting IL-5 levels and studying the molecular mechanisms underlying its immune-modulatory effects.

Product Name:Human IL-5 Polyclonal Antibody
SKU:CAB21170
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat,Other (Wide Range Predicted)
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-134 of human IL-5 (NP_000870.1).
Sequence:IPTE IPTS ALVK ETLA LLST HRTL LIAN ETLR IPVP VHKN HQLC TEEI FQGI GTLE SQTV QGGT VERL FKNL SLIK KYID GQKK KCGE ERRR VNQF LDYL QEFL GVMN TEWI IES
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:EDF; TRF; IL-5; Human IL-5
Positive Sample:Recombinant Human IL-5 Protein
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:15kDa
Observed MW:18-23kDa

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

Purification Method:Affinity purification
Gene ID:3567
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of recombinant Human IL-5 Protein, using Human IL-5 Rabbit pAb (CAB21170) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 10ng/5ng per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.8s.

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