Human IL 29 Recombinant Protein (RPPB0654)
- SKU:
- RPPB0654
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8IU54
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 29 Recombinant Protein |
| Product Code: | RPPB0654 |
| Size: | 20µg |
| Species: | Human |
| Target: | IL 29 |
| Synonyms: | Interleukin-29, IL-29, IFN-Lambda 1, IFN-Lambda 1, Cytokine ZCYTO21, IL29, IFNL1, ZCYTO21. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2 ?m filtered solution containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized IL-29 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IFN-Lambda 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFN-Lambda 1 Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | GPVPTSKPTTT GKGCHIGRFK SLSPQELASF KKARDALEES LKLKNWSCSS PVFPGNWDLR LLQVRERPVA LEAELALTLK VLEAAAGPAL EDVLDQPLHTLHHILSQLQA CIQPQPTAGP RPRGRLHHWL HRLQEAPKKE SAGCLEASVT FNLFRLLTRD LKYVADGNLC LRTSTHPEST |
IL-29 is distantly related to type I IFNs�and the IL-10 family. Expression of IL-29 is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-29 exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumour activity.IL-29 acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1, IFN-lambda 2 and IFN-lambda3 are closely positioned genes on human chromosome 19.IL-29 induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-29 is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-29 produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection. IFN-Lambda 1 antiviral and antiproliferative activity requires IFN-Lambda 2 receptor tyrosine residues.
IL-29 human recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 181 amino acids and having a molecular mass of 20 kDa.
| UniProt Protein Function: | IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted, signal peptide; Secreted; Cell cycle regulation Chromosomal Location of Human Ortholog: 19q13.13 Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex Molecular Function:cytokine activity; interleukin-28 receptor binding; receptor binding Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; positive regulation of interferon-gamma production; negative regulation of interleukin-13 production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of memory T cell differentiation; defense response to virus |
| NCBI Summary: | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IU54 |
| NCBI GenInfo Identifier: | 26024325 |
| NCBI Gene ID: | 282618 |
| NCBI Accession: | NP_742152 |
| UniProt Secondary Accession: | Q8IU54,Q17R34, A0AV25, |
| UniProt Related Accession: | Q8IU54 |
| Molecular Weight: | 22.7kDa (206aa) |
| NCBI Full Name: | interferon lambda-1 |
| NCBI Synonym Full Names: | interferon lambda 1 |
| NCBI Official Symbol: | IFNL1�� |
| NCBI Official Synonym Symbols: | IL29; IL-29�� |
| NCBI Protein Information: | interferon lambda-1 |
| UniProt Protein Name: | Interferon lambda-1 |
| UniProt Synonym Protein Names: | Cytokine Zcyto21; Interleukin-29 |
| UniProt Gene Name: | IFNL1�� |
| UniProt Entry Name: | IFNL1_HUMAN |
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