Human IL 28A Recombinant Protein (RPPB0651)
- SKU:
- RPPB0651
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8IZJ0
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 28A Recombinant Protein |
| Product Code: | RPPB0651 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL 28A |
| Synonyms: | Interleukin-28A, IL-28A, IFN-Lambda 2, Interferon-Lambda 2, Cytokine ZCYTO20, IL28A, IFNL2, ZCYTO20. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL 28A protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVPVARLH GALPDARGCH IAQFKSLSPQ ELQAFKRAKD ALEESLLLKD CRCHSRLFPR TWDLRQLQVR ERPMALEAEL ALTLKVLEAT ADTDPALVDV LDQPLHTLHH ILSQFRACIQ PQPTAGPRTR GRLHHWLYRL QEAPKKESPG CLEASVTFNL FRLLTRDLNC VASGDLCV |
IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumour activity.IL-28A acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1, IFN-lambda 2 and IFN-lambda 3 are closely positioned genes on human chromosome 19.IL-28A induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-28A is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-28A produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.
IL 28A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (26-200 a.a.) and having a molecular mass of 22.1kDa. IL 28A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL28A: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.13 Cellular Component: extracellular region; extracellular space Molecular Function:receptor binding Biological Process: defense response to virus; innate immune response; mucosal immune response; regulation of T cell activation |
| NCBI Summary: | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IZJ0 |
| NCBI GenInfo Identifier: | 55976531 |
| NCBI Gene ID: | 282616 |
| NCBI Accession: | Q8IZJ0.1 |
| UniProt Secondary Accession: | Q8IZJ0,Q45KQ8, Q6VN55, Q8IWL7, |
| UniProt Related Accession: | Q8IZJ0 |
| Molecular Weight: | 22,288 Da |
| NCBI Full Name: | Interferon lambda-2 |
| NCBI Synonym Full Names: | interferon lambda 2 |
| NCBI Official Symbol: | IFNL2�� |
| NCBI Official Synonym Symbols: | IL28A; IL-28A�� |
| NCBI Protein Information: | interferon lambda-2 |
| UniProt Protein Name: | Interferon lambda-2 |
| UniProt Synonym Protein Names: | Cytokine Zcyto20; Interleukin-28A; IL-28A |
| Protein Family: | Interferon |
| UniProt Gene Name: | IFNL2�� |
| UniProt Entry Name: | IFNL2_HUMAN |
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