Human IL 1RA His Recombinant Protein (RPPB0466)
- SKU:
- RPPB0466
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P18510
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 1RA His Recombinant Protein |
| Product Code: | RPPB0466 |
| Size: | 50µg |
| Species: | Human |
| Target: | IL 1RA His |
| Synonyms: | IRAP, IL1F3, IL1RA; IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | Interleukin-1Ra His-tag protein is supplied in 20mM Tris HCl (pH 8) and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
IL-1Ra is produced by a variety of cells including monocytes, macrophages, neutrophils and fibroblasts in response to the binding of various pro-inflammatory cytokines.
IL1Ra Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.63kDa with an amino-terminal hexahistidine tag. The IL-1Ra His is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Vesicle; Cytokine; Secreted Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular Molecular Function:interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity Biological Process: response to drug; positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; response to glucocorticoid stimulus; carboxylic acid metabolic process; response to lipopolysaccharide; female pregnancy; sensory perception of pain; fever; chronic inflammatory response to antigenic stimulus; memory; response to starvation; insulin secretion; acute-phase response; immune response; negative regulation of cytokine and chemokine mediated signaling pathway; response to activity; lipid metabolic process; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis Disease: Microvascular Complications Of Diabetes, Susceptibility To, 4; Gastric Cancer, Hereditary Diffuse; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis |
| NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18510 |
| NCBI GenInfo Identifier: | 124312 |
| NCBI Gene ID: | 3557 |
| NCBI Accession: | P18510.1 |
| UniProt Secondary Accession: | P18510,Q14628, Q53SC2, Q7RTZ4, Q96GD6, Q9UPC0, A8K4G1 |
| UniProt Related Accession: | P18510 |
| Molecular Weight: | 16,142 Da |
| NCBI Full Name: | Interleukin-1 receptor antagonist protein |
| NCBI Synonym Full Names: | interleukin 1 receptor antagonist |
| NCBI Official Symbol: | IL1RN�� |
| NCBI Official Synonym Symbols: | DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA�� |
| NCBI Protein Information: | interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra) |
| UniProt Protein Name: | Interleukin-1 receptor antagonist protein |
| UniProt Synonym Protein Names: | ICIL-1RA; IL1 inhibitor; INN: Anakinra |
| Protein Family: | Interleukin-1 receptor antagonist protein |
| UniProt Gene Name: | IL1RN�� |
| UniProt Entry Name: | IL1RA_HUMAN |
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