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Human IL 17B Recombinant Protein (RPPB0599)

SKU:
RPPB0599
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UHF5
Research Area:
Cytokines
€309
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Description

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Product Name:Human IL 17B Recombinant Protein
Product Code:RPPB0599
Size:25µg
Species:Human
Target:IL 17B
Synonyms:Interleukin-17B, IL-17B, Cytokine Zcyto7, Interleukin-20, Neuronal interleukin-17-related factor, IL20, NIRF, ZCYTO7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Interleukin-17B was Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH7.4, 0.05% Tween-20 and 3%Trehalose.
Solubility:It is recommended to reconstitute the lyophilized Interleukin 17B in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin 17B although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IL17B should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by: (a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F
Biological Activity:The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0�g/ml, corresponding to a specific activity of > 1000 IU/mg.

IL-17 family members are glycoproteins secreted as dimers which induce local cytokine production and recruit granulocytes to sites of inflammation. The IL-17 family is comprised of at least six pro-inflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 is induced by IL-15 and IL-23, mostly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL17B Diseases associated with IL17B include spondyloarthropathy, and neuronitis, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and STAT3 Pathway.

Interleukin-17B Human Recombinant produced in E.Coli is a homodimeric, non-disulfide-linked polypeptide chain containing a total of 322 amino acids (2 chains of 161aa) and having a molecular mass of 36.5kDa. The IL-17B is purified by proprietary chromatographic techniques.

UniProt Protein Function:Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
NCBI Summary:The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
UniProt Code:Q9UHF5
NCBI GenInfo Identifier:20143877
NCBI Gene ID:27190
NCBI Accession:Q9UHF5.1
UniProt Secondary Accession:Q9UHF5,Q14CE5,
UniProt Related Accession:Q9UHF5
Molecular Weight:20,437 Da
NCBI Full Name:Interleukin-17B
NCBI Synonym Full Names:interleukin 17B
NCBI Official Symbol:IL17B��
NCBI Official Synonym Symbols:NIRF; IL-20; IL-17B; ZCYTO7��
NCBI Protein Information:interleukin-17B
UniProt Protein Name:Interleukin-17B
UniProt Synonym Protein Names:Cytokine Zcyto7; Interleukin-20; IL-20; Neuronal interleukin-17-related factor
Protein Family:Interleukin
UniProt Gene Name:IL17B��

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