Human IL 16 Recombinant Protein (RPPB0593)
- SKU:
- RPPB0593
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q14005
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 16 Recombinant Protein |
| Product Code: | RPPB0593 |
| Size: | 25µg |
| Species: | Human |
| Target: | IL 16 |
| Synonyms: | IL16, Interleukin-16, LCF, Lymphocyte Chemoattractant Factor, prIL-16, IL-16, FLJ16806, FLJ42735, FLJ44234, HsT19289. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered solution. |
| Formulation: | IL-16 His tag protein (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM PMSF & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSAGLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS |
IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of IL-16 is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. IL-16 functions exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene.IL-16 stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. Also induces t-lymphocyte expression of interleukin 2 receptor, ligand for cd4.
Interleukin-16 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain (502-631 a.a) containing 150 amino acids and having a molecular mass of 15.5kDa. The IL-16 is fused to a 20 a.a His-Tag at N-Terminus.The IL-16 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL16: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Cytokine; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 15q26.3 Cellular Component: extracellular space; cytoplasm; plasma membrane; nucleus Molecular Function:cytokine activity Biological Process: viral reproduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; leukocyte chemotaxis; immune response; induction of positive chemotaxis |
| NCBI Summary: | The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q14005 |
| NCBI GenInfo Identifier: | 239938922 |
| NCBI Gene ID: | 3603 |
| NCBI Accession: | Q14005.4 |
| UniProt Secondary Accession: | Q14005,Q16435, Q6VVE6, Q6ZMQ7, Q9UP18, A6NM20, A8MU65 B9EGR6, |
| UniProt Related Accession: | Q14005 |
| Molecular Weight: | 66,646 Da |
| NCBI Full Name: | Pro-interleukin-16 |
| NCBI Synonym Full Names: | interleukin 16 |
| NCBI Official Symbol: | IL16�� |
| NCBI Official Synonym Symbols: | LCF; NIL16; PRIL16; prIL-16�� |
| NCBI Protein Information: | pro-interleukin-16; prointerleukin 16; neuronal interleukin 16; lymphocyte chemoattractant factor |
| UniProt Protein Name: | Pro-interleukin-16 |
| UniProt Synonym Protein Names: | Lymphocyte chemoattractant factor; LCF |
| Protein Family: | Pro-interleukin |
| UniProt Gene Name: | IL16�� |
| UniProt Entry Name: | IL16_HUMAN |
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