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Human IGJ Recombinant Protein (RPPB3740)

SKU:
RPPB3740
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01591
€309
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Description

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Product Name:Human IGJ Recombinant Protein
Product Code:RPPB3740
Size:20µg
Species:Human
Target:IGJ
Synonyms:IGCJ, JCH, Immunoglobulin J chain, IGJ.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The IGJ solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQEDERIV LVDNKCKCAR ITSRIIRSSE DPNEDIVERN IRIIVPLNNR ENISDPTSPL RTRFVYHLSD LCKKCDPTEV ELDNQIVTAT QSNICDEDSA TETCYTYDRN KCYTAVVPLV YGGETKMVET ALTPDACYPD

Immunoglobulin J chain (IGJ) helps to link 2 monomer units of either IgM or IgA and also also helps to bind these immunoglobulins to secretory component. When it comes to IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer and in the case of IgA it induces larger polymers.

IGJ Human Recombinant produced in E. coli is a single polypeptide chain containing 160 amino acids (23-159) and having a molecular mass of 18kDa. IGJ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IGJ: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular region; extracellular space

Molecular Function:IgA binding; peptidoglycan binding; phosphatidylcholine binding; protein homodimerization activity; single-stranded DNA binding

Biological Process: adaptive immune response; antibacterial humoral response; glomerular filtration; innate immune response; positive regulation of protein oligomerization; receptor-mediated endocytosis; retinal homeostasis

UniProt Code:P01591
NCBI GenInfo Identifier:261260100
NCBI Gene ID:3512
NCBI Accession:P01591.4
UniProt Related Accession:P01591
Molecular Weight:18,099 Da
NCBI Full Name:Immunoglobulin J chain
NCBI Synonym Full Names:joining chain of multimeric IgA and IgM
NCBI Official Symbol:JCHAIN��
NCBI Official Synonym Symbols:IGJ; JCH; IGCJ��
NCBI Protein Information:immunoglobulin J chain
UniProt Protein Name:Immunoglobulin J chain
UniProt Synonym Protein Names:Joining chain of multimeric IgA and IgM
UniProt Gene Name:JCHAIN��
UniProt Entry Name:IGJ_HUMAN

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