Human IGFBP6 Recombinant Protein (RPPB0436)
- SKU:
- RPPB0436
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P24592
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human IGFBP6 Recombinant Protein |
| Product Code: | RPPB0436 |
| Size: | 20µg |
| Species: | Human |
| Target: | IGFBP6 |
| Synonyms: | IGFBP-6, IBP-6, IGF-binding protein 6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | IBP-6 was lyophilized from a concentrated (1mg/ml) solution containing 1xPBS, 0.1% SDS and 1mM DTT. |
| Solubility: | It is recommended to reconstitute the lyophilized�IGFBP6 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IBP6 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP-6 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
IGFBP6 plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
IGFBP6 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing amino acids 148-240 and having a molecular mass of 20 kDa including 4kDa His tag. IGFBP6 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IGFBP6: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q13 Cellular Component: Golgi apparatus; extracellular space; extracellular region Molecular Function:insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: negative regulation of cell proliferation; regulation of insulin-like growth factor receptor signaling pathway; cellular protein metabolic process; regulation of cell growth; signal transduction |
| UniProt Code: | P24592 |
| NCBI GenInfo Identifier: | 124068 |
| NCBI Gene ID: | 3489 |
| NCBI Accession: | P24592.1 |
| UniProt Secondary Accession: | P24592,Q14492, |
| UniProt Related Accession: | P24592 |
| Molecular Weight: | 25,322 Da |
| NCBI Full Name: | Insulin-like growth factor-binding protein 6 |
| NCBI Synonym Full Names: | insulin-like growth factor binding protein 6 |
| NCBI Official Symbol: | IGFBP6�� |
| NCBI Official Synonym Symbols: | IBP6�� |
| NCBI Protein Information: | insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IGF binding protein 6; IGF-binding protein 6 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 6 |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP6�� |
| UniProt Entry Name: | IBP6_HUMAN |
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