Human IFNW1 Recombinant Protein (RPPB0409)
- SKU:
- RPPB0409
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P05000
- Research Area:
- Cytokines
Description
| Product Name: | Human IFNW1 Recombinant Protein |
| Product Code: | RPPB0409 |
| Size: | 100µg |
| Species: | Human |
| Target: | IFNW1 |
| Synonyms: | IFN omega-1, IFN alpha-II-1, IFNW1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized IFNW1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IFNW1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFNW1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MCDLPQNHGL LSRNTLVLLH QMRRISPFLC LKDRRDFRFP QEMVKGSQLQ KAHVMSVLHE MLQQIFSLFH TERSSAAWNM TLLDQLHTGL HQQLQHLETC LLQVVGEGES AGAISSPALT LRRYFQGIRV YLKEKKYSDC AWEVVRMEIM KSLFLSTNMQ ERLRSKDRDL GSS |
| Biological Activity: | The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is�<�0.01 ng/ml, corresponding to a specific activity of�>�100,000,000 units/mg. |
IFN-Omega 1 is a type I IFN, that can be induced by virus-infected leukocytes. Type I IFN family members, which include IFN-alpha, IFN-beta, and IFN-omega, signal through IFNAR-1/IFNAR-2 receptor complex, and wield antiviral and antiproliferative activities. IFNW1 exhibits about 75% sequence homology with IFN-a, and contains 2 conserved disulfide bonds, which are essential for full biological activity.
IFN-Omega 1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19.9kDa.The IFN-Omega 1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IFNW1: Belongs to the alpha/beta interferon family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9p22 Cellular Component: extracellular space Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interferon-alpha/beta receptor binding; cytokine activity Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; B cell differentiation; natural killer cell activation during immune response; innate immune response; cell cycle arrest; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein |
| UniProt Code: | P05000 |
| NCBI GenInfo Identifier: | 400061 |
| NCBI Gene ID: | 3467 |
| NCBI Accession: | P05000.2 |
| UniProt Secondary Accession: | P05000,Q13168, Q5U802, Q5VWD0, Q7M4P5, |
| UniProt Related Accession: | P05000 |
| Molecular Weight: | 22,319 Da |
| NCBI Full Name: | Interferon omega-1 |
| NCBI Synonym Full Names: | interferon, omega 1 |
| NCBI Official Symbol: | IFNW1�� |
| NCBI Protein Information: | interferon omega-1; interferon alpha-II-1; IFN-omega 1, interferon omega-1 |
| UniProt Protein Name: | Interferon omega-1 |
| UniProt Synonym Protein Names: | Interferon alpha-II-1 |
| UniProt Gene Name: | IFNW1�� |
| UniProt Entry Name: | IFNW1_HUMAN |
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