Human IFN b 1b Recombinant Protein (RPPB0394)
- SKU:
- RPPB0394
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P01574
- Research Area:
- Cytokines
Description
| Product Name: | Human IFN b 1b Recombinant Protein |
| Product Code: | RPPB0394 |
| Size: | 10µg |
| Species: | Human |
| Target: | IFN b 1b |
| Synonyms: | Leukocyte IFN, B cell IFN, Type I IFN, IFNB1, IFB, IFF, IFNB, IFN-b 1b, MGC96956. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from 1mg/ml solution containing 50mg Human Albumin & 50mg dextrose. |
| Solubility: | It is recommended to reconstitute the lyophilized IFN beta-1b in sterile 18M-cm H2O at a concentration of 0.25mg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IFN-beta 1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFNB 1b should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Tyr-Asn-Leu-Leu |
| Biological Activity: | The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 32 x 106 IU/mg. |
IFN-beta 1b has antiviral, antibacterial and anticancer activities.
IFN beta 1b Human Recombinant produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IFN beta-1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510.86 Dalton.The IFN-beta gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine residue found at position 17. IFN beta-1b is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 9p21 Cellular Component: extracellular space; extracellular region Molecular Function:interferon-alpha/beta receptor binding; cytokine activity Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein |
| UniProt Code: | P01574 |
| NCBI GenInfo Identifier: | 124469 |
| NCBI Gene ID: | 3456 |
| NCBI Accession: | P01574.1 |
| UniProt Secondary Accession: | P01574,Q5VWC9, |
| UniProt Related Accession: | P01574 |
| Molecular Weight: | 187 |
| NCBI Full Name: | Interferon beta |
| NCBI Synonym Full Names: | interferon, beta 1, fibroblast |
| NCBI Official Symbol: | IFNB1�� |
| NCBI Official Synonym Symbols: | IFB; IFF; IFNB�� |
| NCBI Protein Information: | interferon beta; IFN-beta; fibroblast interferon |
| UniProt Protein Name: | Interferon beta |
| UniProt Synonym Protein Names: | Fibroblast interferon |
| Protein Family: | Interferon |
| UniProt Gene Name: | IFNB1�� |
| UniProt Entry Name: | IFNB_HUMAN |
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