Human ICAM1 Recombinant Protein (RPPB3726)
- SKU:
- RPPB3726
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P05362
Description
| Product Name: | Human ICAM1 Recombinant Protein |
| Product Code: | RPPB3726 |
| Size: | 10µg |
| Species: | Human |
| Target: | ICAM1 |
| Synonyms: | Intercellular Adhesion Molecule 1, Major Group RhinovirusReceptor, ICAM-1, Intercellular Adhesion Molecule 1 (CD54), Human RhinovirusReceptor, Cell Surface Glycoprotein P3.58, Human Rhinovirus Receptor, CD54Antigen, P3.58, CD54, BB2, Intercellular adhesion molecule 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ICAM1 protein solution (0.25mg/ml) contains phosphatebuffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QTSVSPSKVILPRGGSVLVT CSTSCDQPKL LGIETPLPKK ELLLPGNNRK VYELSNVQED SQPMCYSNCP DGQSTAKTFLTVYWTPERVE LAPLPSWQPV GKNLTLRCQV EGGAPRANLT VVLLRGEKEL KREPAVGEPA EVTTTVLVRRDHHGANFSCR TELDLRPQGL ELFENTSAPY QLQTFVLPAT PPQLVSPRVL EVDTQGTVVC SLDGLFPVSEAQVHLALGDQ RLNPTVTYGN DSFSAKASVS VTAEDEGTQR LTCAVILGNQ SQETLQTVTI YSFPAPNVILTKPEVSEGTE VTVKCEAHPR AKVTLNGVPA QPLGPRAQLL LKATPEDNGR SFSCSATLEV AGQLIHKNQTRELRVLYGPR LDERDCPGNW TWPENSQQTP MCQAWGNPLP ELKCLKDGTF PLPIGESVTV TRDLEGTYLCRARSTQGEVT REVTVNVLSP RYEVEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTCVVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAPIEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSDGSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYRQKSL SLSPGKHHHH HH |
ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic and haematopoietic cell types and has roles in signal transduction, cell signaling and lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18, or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes and endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFA) and is expressed by the vascular endothelium, macrophages and lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 is implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be notably elevated in patients with SAH. �Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions.
ICAM1 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 692 amino acids (28-480a.a.) andhaving a molecular mass of 76.5kDa. (Molecular size on SDS-PAGE will appear atapproximately 70-100kDa).ICAM1 is expressed with a 239 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19p13.3-p13.2 Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane Molecular Function:viral receptor activity; integrin binding; protein binding; transmembrane receptor activity; receptor activity Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; response to drug; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration Disease: Malaria, Susceptibility To |
| NCBI Summary: | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05362 |
| NCBI GenInfo Identifier: | 68067956 |
| NCBI Gene ID: | 3383 |
| NCBI Accession: | P05362.2 |
| UniProt Secondary Accession: | P05362,Q5NKV7, Q96B50, B2R6M3, |
| UniProt Related Accession: | P05362 |
| Molecular Weight: | |
| NCBI Full Name: | Intercellular adhesion molecule 1 |
| NCBI Synonym Full Names: | intercellular adhesion molecule 1 |
| NCBI Official Symbol: | ICAM1�� |
| NCBI Official Synonym Symbols: | BB2; CD54; P3.58�� |
| NCBI Protein Information: | intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor |
| UniProt Protein Name: | Intercellular adhesion molecule 1 |
| UniProt Synonym Protein Names: | Major group rhinovirus receptor; CD_antigen: CD54 |
| Protein Family: | Intercellular adhesion molecule |
| UniProt Gene Name: | ICAM1�� |
| UniProt Entry Name: | ICAM1_HUMAN |
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