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Human HSD17B11 Recombinant Protein (RPPB1833)

SKU:
RPPB1833
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8NBQ5
Research Area:
Enzymes
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Description

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Product Name:Human HSD17B11 Recombinant Protein
Product Code:RPPB1833
Size:20µg
Species:Human
Target:HSD17B11
Synonyms:17-beta-hydroxysteroid dehydrogenase 11, 17-beta-HSD 11, 17bHSD11, 17betaHSD11, 17-beta-hydroxysteroid dehydrogenase XI, 17-beta-HSD XI, 17betaHSDXI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, CTCL-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2, retSDR2, HSD17B11, DHRS8, PAN1B, SDR16C2, 17BHSD11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The HSD17B11 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MESFVKLFIP KRRKSVTGEI VLITGAGHGI GRLTAYEFAK LKSKLVLWDI NKHGLEETAA KCKGLGAKVH TFVVDCSNRE DIYSSAKKVK AEIGDVSILV NNAGVVYTSD LFATQDPQIE KTFEVNVLAH FWTTKAFLPA MTKNNHGHIV TVASAAGHVS VPFLLAYCSS KFAAVGFHKT LTDELAALQI TGVKTTCLCP NFVNTGFIKN PSTSLGPTLE PEEVVNRLMH GILTEQKMIF IPSSIAFLTT LERILPERFL AVLKQKI

Dehydrogenase/reductase SDR family member 8 (HSD17B11) is a member of the HSD17B family of proteins, which regulate the availability of steroids within various tissues throughout the body. HSD17B11 is widely expressed with the highest levels found in the retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart as well as in steroidogenic cells.

HSD17B11 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 287 amino acids (20-285 a.a.) and having a molecular mass of 31.4kDa. The HSD17B11 is purified by proprietary chromatographic techniques.

UniProt Protein Function:HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.Protein type: Secreted, signal peptide; Secreted; Oxidoreductase; EC 1.1.1.62Chromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particleMolecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activityBiological Process: androgen catabolic process; estrogen biosynthetic process
UniProt Protein Details:
NCBI Summary:Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
UniProt Code:Q8NBQ5
NCBI GenInfo Identifier:296439374
NCBI Gene ID:51170
NCBI Accession:Q8NBQ5.3
UniProt Secondary Accession:Q8NBQ5,Q96HF6, Q9UKU4
UniProt Related Accession:Q8NBQ5
Molecular Weight:32,936 Da
NCBI Full Name:Estradiol 17-beta-dehydrogenase 11
NCBI Synonym Full Names:hydroxysteroid 17-beta dehydrogenase 11
NCBI Official Symbol:HSD17B11��
NCBI Official Synonym Symbols:DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI��
NCBI Protein Information:estradiol 17-beta-dehydrogenase 11
UniProt Protein Name:Estradiol 17-beta-dehydrogenase 11
UniProt Synonym Protein Names:17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Short chain dehydrogenase/reductase family 16C member 2
Protein Family:Estradiol 17 beta-dehydrogenase
UniProt Gene Name:HSD17B11��
UniProt Entry Name:DHB11_HUMAN

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