Human HLF Recombinant Protein (RPPB3694)
- SKU:
- RPPB3694
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16534
Description
| Product Name: | Human HLF Recombinant Protein |
| Product Code: | RPPB3694 |
| Size: | 5µg |
| Species: | Human |
| Target: | HLF |
| Synonyms: | Hepatic leukemia factor, HLF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | HLF protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.2M NaCl and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEKMSRPLPL NPTFIPPPYG VLRSLLENPL KLPLHHEDAF SKDKDKEKKL DDESNSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS PSQHDHSPHP PGLQPASSAA PSVMDLSSRA SAPLHPGIPS PNCMQSPIRP GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGQ EMFDPRKRKF SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL |
Hepatic leukemia factor (HLF) is a member of the bZIP family and the PAR (proline and acidic-rich) subfamily of transcription regulatory proteins. HLF binds DNA specifically as a homodimer or heterodimer with other PAR factors. HLF is highly expressed in the liver, with lower levels in the lung and kidney and functions as an effective trans-activator.
HLF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-295 a.a.) and having a molecular mass of 35.3kDa.HLF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HLF: A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3. Belongs to the bZIP family. PAR subfamily. |
| UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 17q22 Cellular Component: nucleus Molecular Function:DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; multicellular organismal development; rhythmic process |
| NCBI Summary: | This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16534 |
| NCBI GenInfo Identifier: | 6919907 |
| NCBI Gene ID: | 3131 |
| NCBI Accession: | Q16534.1 |
| UniProt Secondary Accession: | Q16534,Q6FHS9, A8K1X8, |
| UniProt Related Accession: | Q16534 |
| Molecular Weight: | 295 |
| NCBI Full Name: | Hepatic leukemia factor |
| NCBI Synonym Full Names: | hepatic leukemia factor |
| NCBI Official Symbol: | HLF�� |
| NCBI Protein Information: | hepatic leukemia factor |
| UniProt Protein Name: | Hepatic leukemia factor |
| Protein Family: | Hepatic leukemia factor |
| UniProt Gene Name: | HLF�� |
| UniProt Entry Name: | HLF_HUMAN |
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