Human HINT1 Recombinant Protein (RPPB3683)
- SKU:
- RPPB3683
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P49773
Description
| Product Name: | Human HINT1 Recombinant Protein |
| Product Code: | RPPB3683 |
| Size: | 20µg |
| Species: | Human |
| Target: | HINT1 |
| Synonyms: | HINT, PKCI-1, PRKCNH1, FLJ30414, FLJ32340, HINT1, Histidine triad nucleotide-binding protein 1, Adenosine 5'-monophosphoramidase, Protein kinase C inhibitor 1, Protein kinase C-interacting protein 1, PKCI1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HINT1 solution contains 20mM Tris pH-8 & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG |
HINT1 hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Though it was initially considered to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- , its actual physiologic function is not known.
HINT1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 126 amino acids (1-126 a.a.) and having a molecular mass of 13.8 kDa.The HINT1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HINT1: Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha- acetyl lysine methyl ester and AMP-NH2. Belongs to the HINT family. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.-.-.-; Cytoskeletal Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: cytoskeleton; histone deacetylase complex; cytoplasm; plasma membrane; nucleus Molecular Function:protein kinase C binding; hydrolase activity; nucleotide binding Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; purine ribonucleotide catabolic process; signal transduction Disease: Neuromyotonia And Axonal Neuropathy, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P49773 |
| NCBI GenInfo Identifier: | 1708543 |
| NCBI Gene ID: | 3094 |
| NCBI Accession: | P49773.2 |
| UniProt Secondary Accession: | P49773,Q9H5W8, |
| UniProt Related Accession: | P49773 |
| Molecular Weight: | 126 |
| NCBI Full Name: | Histidine triad nucleotide-binding protein 1 |
| NCBI Synonym Full Names: | histidine triad nucleotide binding protein 1 |
| NCBI Official Symbol: | HINT1�� |
| NCBI Official Synonym Symbols: | HINT; NMAN; PKCI-1; PRKCNH1�� |
| NCBI Protein Information: | histidine triad nucleotide-binding protein 1; protein kinase C inhibitor 1; adenosine 5'-monophosphoramidase; protein kinase C-interacting protein 1 |
| UniProt Protein Name: | Histidine triad nucleotide-binding protein 1 |
| UniProt Synonym Protein Names: | Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1 |
| Protein Family: | Adenylylsulfatase |
| UniProt Gene Name: | HINT1�� |
| UniProt Entry Name: | HINT1_HUMAN |
