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Human HES7 Recombinant Protein (RPPB3675)

SKU:
RPPB3675
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BYE0
€469
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Description

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Product Name:Human HES7 Recombinant Protein
Product Code:RPPB3675
Size:20µg
Species:Human
Target:HES7
Synonyms:Hairy and enhancer of split 7, bHLHb37, SCDO4, Transcription factor HES-7, HES7, hHes7, Class B basic helix-loop-helix protein 37, bHLH factor Hes7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The HES7 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMVTRDRA ENRDGPKMLK PLVEKRRRDR INRSLEELRL LLLERTRDQN LRNPKLEKAE ILEFAVGYLR ERSRVEPPAA AAPGVPRSPV QDAEALASCY LSGFRECLLR LAAFAHDASP AARAQLFSAL HGYLRPKPPR PKPVDPRPPA PRPSLDPAAP ALGPALHQRP PVHQGHPSPR CAWSPSLCSP RAGDSGAPAP LTGLLPPPPP PHRQDGAPKA PLPPPPAFWR PWP

HES7 belongs to the Hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of the HES7 is set by Notch signaling. The protein serves as a transcriptional repressor, and is involved in correct patterning of the axial skeleton. A mutation in HES7 has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been discovered for HES7.

HES7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 253 amino acids (1-230) and having a molecular mass of 27kDa. HES7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HES7: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4). A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.Chromosomal Location of Human Ortholog: 17p13.1Disease: Spondylocostal Dysostosis 4, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:Q9BYE0
NCBI GenInfo Identifier:296434525
NCBI Gene ID:84667
NCBI Accession:Q9BYE0.2
UniProt Secondary Accession:Q9BYE0,F8VPC9
UniProt Related Accession:Q9BYE0
Molecular Weight:25,280 Da
NCBI Full Name:Transcription factor HES-7
NCBI Synonym Full Names:hes family bHLH transcription factor 7
NCBI Official Symbol:HES7��
NCBI Official Synonym Symbols:SCDO4; bHLHb37��
NCBI Protein Information:transcription factor HES-7
UniProt Protein Name:Transcription factor HES-7
UniProt Synonym Protein Names:Class B basic helix-loop-helix protein 37; bHLHb37; Hairy and enhancer of split 7; bHLH factor Hes7
Protein Family:Transcription factor
UniProt Gene Name:HES7��
UniProt Entry Name:HES7_HUMAN

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