Human HDAC2 Recombinant Protein (RPPB1800)
- SKU:
- RPPB1800
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92769
- Research Area:
- Enzymes
Description
| Product Name: | Human HDAC2 Recombinant Protein |
| Product Code: | RPPB1800 |
| Size: | 10µg |
| Species: | Human |
| Target: | HDAC2 |
| Synonyms: | Histone deacetylase 2, YAF1, HD2, YY1-associated factor 1, transcriptional regulator homolog RPD3, RPD3, EC 3.5.1.98. |
| Source: | Hi-5 cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HDAC2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl, 0.1mM PMSF and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHHGDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYMEKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT KSEQLSNPSR HHHHHH |
HDAC2 is a member of the histone deacetylase family that performs through the construction of large multiprotein complexes and are in charge of the deacetylation of lysine residues on the N-terminal region of the core histones. HDAC2 forms transcriptional repressor complexes by relating to a diversity of proteins, like YY1- a mammalian zinc-finger transcription factor. In addition, HDAC2 has a vital part in transcriptional regulation, cell cycle progression and developmental procedures.
HDAC2 Human Recombinant produced in Hi-5 Cell is a single, non-glycosylated polypeptide chain containing 496 amino acids (1-488) and having a molecular mass of 56.4 kDa.The HDAC2 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HDAC2: a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
| UniProt Protein Details: | Protein type:EC 3.5.1.98; Transcription, coactivator/corepressor; Deacetylase; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleoplasm; heterochromatin; transcription factor complex; protein complex; Sin3 complex; ESC/E(Z) complex; cytoplasm; nuclear chromatin; replication fork; NuRD complex; nucleus Molecular Function:deacetylase activity; nucleosomal DNA binding; protein deacetylase activity; transcription factor binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; heat shock protein binding; chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor activity Biological Process: establishment and/or maintenance of chromatin architecture; nerve growth factor receptor signaling pathway; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; negative regulation of cell cycle; cardiac muscle cell development; negative regulation of cardiac muscle cell proliferation; negative regulation of gene expression, epigenetic; positive regulation of cell proliferation; dendrite development; circadian regulation of gene expression; positive regulation of oligodendrocyte differentiation; response to drug; transcription, DNA-dependent; negative regulation of transcription factor activity; hippocampus development; histone deacetylation; regulation of protein kinase B signaling cascade; response to cocaine; odontogenesis of dentine-containing teeth; chromatin remodeling; maintenance of chromatin silencing; negative regulation of MHC class II biosynthetic process; ATP-dependent chromatin remodeling; epidermal cell differentiation; positive regulation of transcription factor activity; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; blood coagulation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis |
| NCBI Summary: | This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] |
| UniProt Code: | Q92769 |
| NCBI GenInfo Identifier: | 68068066 |
| NCBI Gene ID: | 3066 |
| NCBI Accession: | Q92769.2 |
| UniProt Secondary Accession: | Q92769,Q5SRI8, Q5SZ86, Q8NEH4, B3KRS5, B4DL58, E1P561 |
| UniProt Related Accession: | Q92769 |
| Molecular Weight: | 488 |
| NCBI Full Name: | Histone deacetylase 2 |
| NCBI Synonym Full Names: | histone deacetylase 2 |
| NCBI Official Symbol: | HDAC2�� |
| NCBI Official Synonym Symbols: | HD2; RPD3; YAF1�� |
| NCBI Protein Information: | histone deacetylase 2; YY1-associated factor 1; transcriptional regulator homolog RPD3 |
| UniProt Protein Name: | Histone deacetylase 2 |
| UniProt Gene Name: | HDAC2�� |
| UniProt Entry Name: | HDAC2_HUMAN |
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