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Human HBXIP Recombinant Protein (RPPB5508)

SKU:
RPPB5508
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43504
Research Area:
Viral Antigens
€309
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Description

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Product Name:Human HBXIP Recombinant Protein
Product Code:RPPB5508
Size:20µg
Species:Human
Target:HBXIP
Synonyms:Ragulator complex protein LAMTOR5, Hepatitis B virus X-interacting protein, HBV X-interacting protein, HBX-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5, LAMTOR5, HBXIP, XIP.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The HBXIP solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMEPGAG HLDGHRAGSP SLRQALCDGS AVMFSSKERG RCTVINFVPL EAPLRSTPRS RQVTEACGGE GRAVPLGSEP EWSVGGMEAT LEQHLEDTMK NPSIVGVLCT DSQGLNLGCR GTLSDEHAGV ISVLAQQAAK LTSDPTDIPV VCLESDNGNI MIQKHDGITV AVHKMAS

Hepatitis B virus x interacting protein (HBXIP) forms a complex with the C-terminus of hepatitis B virus X (HBX) protein. HBXIP negatively regulates HBX activity and changes the replicative life cycle of the virus. Furthermore, HBXIP is involved in bipolar spindle formation and regulates centrosome dynamics and cytokinesis in cells, possibly due to interaction with Dynein light chain. HBXIP is highly expressed in the skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. HBXIP has elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

HBXIP Human Recombinant produced in E. coli is a single polypeptide chain containing 197 amino acids (aa 1-173) and having a molecular mass of 20.7kDa.HBXIP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Code:O43504
NCBI GenInfo Identifier:2745883
NCBI Gene ID:10542
NCBI Accession:AAC52032.1
UniProt Secondary Accession:O43504,Q6IBD8,
UniProt Related Accession:O43504
Molecular Weight:9,614 Da
NCBI Full Name:hepatitis B virus X interacting protein
NCBI Synonym Full Names:late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
NCBI Official Symbol:LAMTOR5��
NCBI Official Synonym Symbols:XIP; HBXIP��
NCBI Protein Information:ragulator complex protein LAMTOR5
UniProt Protein Name:Ragulator complex protein LAMTOR5
UniProt Synonym Protein Names:Hepatitis B virus X-interacting protein; HBV X-interacting protein; HBX-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
UniProt Gene Name:LAMTOR5��

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