Human HAVCR1 Recombinant Protein (RPPB5498)
- SKU:
- RPPB5498
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96D42
- Research Area:
- Viral Antigens
Description
| Product Name: | Human HAVCR1 Recombinant Protein |
| Product Code: | RPPB5498 |
| Size: | 10µg |
| Species: | Human |
| Target: | HAVCR1 |
| Synonyms: | Hepatitis A Virus Cellular Receptor 1, T-Cell Immunoglobulin Mucin Family Member 1, T-Cell Immunoglobulin Mucin Receptor 1, T-Cell Membrane Protein 1, Kidney Injury Molecule 1, HAVCR-1, TIMD-1, HAVCR, KIM-1, TIM-1, TIMD1, TIM1, KIM1, TIM, T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1, T Cell Immunoglobin Domain And Mucin Domain Protein 1, HAVCR1. |
| Source: | HEK293 Cells |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | HAVCR1 was filtered (0.4�m) and lyophilized from 0.5mg/ml solution in phosphate buffered saline and 5% (w/v) Trehalose. |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. HAVCR1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ASSVKVGGEA GPSVTLPCHY SGAVTSMCWN RGSCSLFTCQ NGIVWTNGTH VTYRKDTRYK LLGDLSRRDV SLTIENTAVS DSGVYCCRVE HRGWFNDMKI TVSLEIVPPK VTTTPIVTTV PTVTTVRTST TVPTTTTVPM TTVPTTTVPT TMSIPTTTTV LTTMTVSTTT SVPTTTSIPT TTSVPVTTTV STFVPPMPLP RQNHEPVATS PSSPQPAETH PTTLQGAIRR EPTSSPLYSY TTDGNDTVTE SSDGLWNNNQ TQLFLEHSLL TANTTKLHHH HHH |
Hepatitis A virus cellular receptor 1 (HAVCR1) is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. HAVCR1 is a type I trans-membrane structural glycoprotein located in the renal proximal tubule epithelial cells. HAVCR1 protein may be involved in the control of asthma and allergic diseases. The reference genome represents an allele which retains a MTTVP amino acid segment that presents defense against atopy in HHAV seropositive individuals.
HAVCR1 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Ser21-Thr288) containing a total of 283 amino acids, having a calculated molecular mass of 30.5kDa. HAVCR1 is fused to a 2 aa N-terminal linker, a 2 aa C-terminal linker and a 6 aa His tag at C-Terminus.
| UniProt Protein Function: | TIM-1: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Belongs to the immunoglobulin superfamily. TIM family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 5q33.2 Cellular Component: integral to membrane Molecular Function:viral receptor activity Biological Process: entry of virus into host cell Disease: Ige Responsiveness, Atopic |
| NCBI Summary: | The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q96D42 |
| NCBI GenInfo Identifier: | 73919877 |
| NCBI Gene ID: | 26762 |
| NCBI Accession: | Q96D42.2 |
| UniProt Secondary Accession: | Q96D42,O43656, |
| UniProt Related Accession: | Q96D42 |
| Molecular Weight: | 364 |
| NCBI Full Name: | Hepatitis A virus cellular receptor 1 |
| NCBI Synonym Full Names: | hepatitis A virus cellular receptor 1 |
| NCBI Official Symbol: | HAVCR1�� |
| NCBI Official Synonym Symbols: | TIM; KIM1; TIM1; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1�� |
| NCBI Protein Information: | hepatitis A virus cellular receptor 1; kidney injury molecule 1; T-cell membrane protein 1; T-cell immunoglobulin mucin receptor 1; T-cell immunoglobulin mucin family member 1; T cell immunoglobin domain and mucin domain protein 1 |
| UniProt Protein Name: | Hepatitis A virus cellular receptor 1 |
| UniProt Synonym Protein Names: | Kidney injury molecule 1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T-cell immunoglobulin mucin receptor 1; TIM; TIM-1; T-cell membrane protein 1 |
| UniProt Gene Name: | HAVCR1�� |
| UniProt Entry Name: | HAVR1_HUMAN |
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