Human HAND1 Recombinant Protein (RPPB3655)
- SKU:
- RPPB3655
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O96004
Description
| Product Name: | Human HAND1 Recombinant Protein |
| Product Code: | RPPB3655 |
| Size: | 20µg |
| Species: | Human |
| Target: | HAND1 |
| Synonyms: | Heart- And Neural Crest Derivatives-Expressed Protein 1, Extraembryonic Tissues Heart Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1, Class A Basic Helix-Loop-Helix Protein 27, BHLHa27, EHAND, Thing1, Hxt. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HAND1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMNLVGSY AHHHHHHHPH PAHPMLHEPF LFGPASRCHQ ERPYFQSWLL SPADAAPDFP AGGPPPAAAA AATAYGPDAR PGQSPGRLEA LGGRLGRRKG SGPKKERRRT ESINSAFAEL RECIPNVPAD TKLSKIKTLR LATSYIAYLM DVLAKDAQSG DPEAFKAELK KADGGRESKR KRELQQHEGF PPALGPVEKR IKGRTGWPQQ VWALELNQ |
HAND1 is a member of the basic helix-loop-helix family of transcription factors. HAND1 is one of two HAND proteins, two closely related family members that are irregularly expressed in the emerging ventricular chambers and have a key part in cardiac morphogenesis. Operating in a complementary manner, they work in the development of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. Furthermore, HAND1 is obligatory for early trophoblast differentiation.
HAND1 Human Recombinant produced in E. coli is a single polypeptide chain containing 238 amino acids (1-215) and having a molecular mass of 26.0 kDa.HAND1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HAND1: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). |
| UniProt Protein Details: | Protein type:Transcription factor; Nucleolus; Cell development/differentiation; DNA-binding Chromosomal Location of Human Ortholog: 5q33 Cellular Component: cytoplasm; nucleus Molecular Function:bHLH transcription factor binding; identical protein binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding Biological Process: angiogenesis; blastocyst development; embryonic heart tube development; heart development; heart looping; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; trophectodermal cell differentiation; ventricular cardiac muscle morphogenesis |
| NCBI Summary: | The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O96004 |
| NCBI GenInfo Identifier: | 10720015 |
| NCBI Gene ID: | 9421 |
| NCBI Accession: | O96004.1 |
| UniProt Related Accession: | O96004 |
| Molecular Weight: | 23,627 Da |
| NCBI Full Name: | Heart- and neural crest derivatives-expressed protein 1 |
| NCBI Synonym Full Names: | heart and neural crest derivatives expressed 1 |
| NCBI Official Symbol: | HAND1�� |
| NCBI Official Synonym Symbols: | Hxt; eHand; Thing1; bHLHa27�� |
| NCBI Protein Information: | heart- and neural crest derivatives-expressed protein 1 |
| UniProt Protein Name: | Heart- and neural crest derivatives-expressed protein 1 |
| UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 27; bHLHa27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND |
| Protein Family: | Heart- and neural crest derivatives-expressed protein |
| UniProt Gene Name: | HAND1�� |
| UniProt Entry Name: | HAND1_HUMAN |
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