Human GZMK Recombinant Protein (RPPB1786)
- SKU:
- RPPB1786
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P49863
- Research Area:
- Enzymes
Description
| Product Name: | Human GZMK Recombinant Protein |
| Product Code: | RPPB1786 |
| Size: | 10µg |
| Species: | Human |
| Target: | GZMK |
| Synonyms: | GZMK, TRYP2, Granzyme-K, Granzyme K, Fragmentin-3, Granzyme-3, NK-tryptase-2, NK-Tryp-2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | GZMK protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT.� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by analysis by SDS-PAGE. |
| Amino Acid Sequence: | ADPIIGGKEV SPHSRPFMAS IQYGGHHVCG GVLIDPQWVL TAAHCQYRFT KGQSPTVVLG AHSLSKNEAS KQTLEIKKFI PFSRVTSDPQ SNDIMLVKLQ TAAKLNKHVK MLHIRSKTSL RSGTKCKVTG WGATDPDSLR PSDTLREVTV TVLSRKLCNS QSYYNGDPFI TKDMVCAGDA KGQKDSCKGD SGGPLICKGV FHAIVSGGHE CGVATKPGIY TLLTKKYQTW IKSNLVPPHT NHHHHHH |
GZMK is a part of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes and natural killer cells have the outstanding ability to bind, recognize and lyse specific target cells. They defend their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens.
GZMK Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 247 amino acids (27-264) and having a molecular mass of 26.9kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). GZMK is fused to a 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.�
| NCBI Summary: | This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49863 |
| NCBI GenInfo Identifier: | 1708035 |
| NCBI Gene ID: | 3003 |
| NCBI Accession: | P49863.1 |
| UniProt Secondary Accession: | P49863,B2R563, |
| UniProt Related Accession: | P49863 |
| Molecular Weight: | |
| NCBI Full Name: | Granzyme K |
| NCBI Synonym Full Names: | granzyme K |
| NCBI Official Symbol: | GZMK�� |
| NCBI Official Synonym Symbols: | TRYP2�� |
| NCBI Protein Information: | granzyme K |
| UniProt Protein Name: | Granzyme K |
| UniProt Synonym Protein Names: | Fragmentin-3; Granzyme-3; NK-tryptase-2; NK-Tryp-2 |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMK�� |
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