Human GYPC Recombinant Protein (RPPB3651)
- SKU:
- RPPB3651
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P04921
Description
| Product Name: | Human GYPC Recombinant Protein |
| Product Code: | RPPB3651 |
| Size: | 10µg |
| Species: | Human |
| Target: | GYPC |
| Synonyms: | Glycophorin C (Gerbich Blood Group), Sialoglycoprotein D, Glycoprotein Beta, Glycoconnectin, Glycophorin-D, PAS-2, GPD 3 4, GPC, Glycophorin-C, CD236 Antigen, CD236R, CD236, GYPD, GLPC, GE, Glycophorin-C, Glycoconnectin, Glycophorin-D, GPD, Glycoprotein beta, PAS-2', Sialoglycoprotein D. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | GYPC protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPMWSTRSP NSTAWPLSLE PDPGMASAST TMHTTTIAEP DPGMSGWPDG RMETSTPTIM HHHHHH |
Glycophorin C, also known as GYPC, �is an integral membrane glycoprotein. GYPC is a minor species which is carried by human erythrocytes, however plays an important role in regulating the mechanical stability of red cells. Numeral glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 & 2, respectively. The Webb & Duch antigens, also identified as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very slight homology with glycophorins A & B.
GYPC Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 66 amino acids (1-57a.a.) and having a molecular mass of 7.2kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). GYPC is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GYPC: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. Belongs to the glycophorin-C family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q14-q21 Cellular Component: cortical cytoskeleton; membrane; integral to plasma membrane; plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To; Blood Group, Gerbich System |
| NCBI Summary: | Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| UniProt Code: | P04921 |
| NCBI GenInfo Identifier: | 121407 |
| NCBI Gene ID: | 2995 |
| NCBI Accession: | P04921.1 |
| UniProt Secondary Accession: | P04921,Q53SV9, Q92642, B2R522, |
| UniProt Related Accession: | P04921 |
| Molecular Weight: | 128 |
| NCBI Full Name: | Glycophorin-C |
| NCBI Synonym Full Names: | glycophorin C (Gerbich blood group) |
| NCBI Official Symbol: | GYPC�� |
| NCBI Official Synonym Symbols: | GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2'�� |
| NCBI Protein Information: | glycophorin-C; glycophorin-D; glycoconnectin; glycoprotein beta; sialoglycoprotein D |
| UniProt Protein Name: | Glycophorin-C |
| UniProt Synonym Protein Names: | Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD_antigen: CD236 |
| Protein Family: | Glycophorin |
| UniProt Gene Name: | GYPC�� |
| UniProt Entry Name: | GLPC_HUMAN |
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