Human GSTM4 Recombinant Protein (RPPB1767)
- SKU:
- RPPB1767
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q03013
- Research Area:
- Enzymes
Description
| Product Name: | Human GSTM4 Recombinant Protein |
| Product Code: | RPPB1767 |
| Size: | 20µg |
| Species: | Human |
| Target: | GSTM4 |
| Synonyms: | Glutathione S-transferase Mu 4, EC=2.5.1.18, GST class-mu 4, GST-Mu2, GSTM4-4, GSTM4, GTM4, GSTM4-4, MGC9247, MGC131945. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | GSTM4 Human solution containing 20mM Tris-HCl pH-8, 1mM DTT, 0.05M NaCl & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSMTLGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQAMDVSNQ LARVCYSPDF EKLKPEYLEE LPTMMQHFSQ FLGKRPWFVG DKITFVDFLA YDVLDLHRIF EPNCLDAFPN LKDFISRFEG LEKISAYMKS SRFLPKPLYT RVAVWGNK |
GSTM4 is part of the glutathione s-transferase (GST) family of proteins. There are eight families of GST proteins, namely alpha, kappa, mu, omega, pi, sigma, theta and zeta, each of which is composed of proteins that have a variety of functions throughout the cell. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.
GSTM4 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 238 amino acids (1-218 a.a.) and having a molecular mass of 27.7 kDa. The GSTM4 is fused to a 20 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GSTM4: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene. Belongs to the GST superfamily. Mu family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: cytoplasm; cytosol Molecular Function:enzyme binding; glutathione binding; glutathione transferase activity; protein binding; protein homodimerization activity Biological Process: glutathione metabolic process; xenobiotic catabolic process |
| NCBI Summary: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q03013 |
| NCBI GenInfo Identifier: | 1170096 |
| NCBI Gene ID: | 2948 |
| NCBI Accession: | Q03013.3 |
| UniProt Secondary Accession: | Q03013,Q05465, Q32NC1, Q4JNT8, Q6FH87, A8K765, |
| UniProt Related Accession: | Q03013 |
| Molecular Weight: | 18,627 Da |
| NCBI Full Name: | Glutathione S-transferase Mu 4 |
| NCBI Synonym Full Names: | glutathione S-transferase mu 4 |
| NCBI Official Symbol: | GSTM4�� |
| NCBI Official Synonym Symbols: | GTM4; GSTM4-4�� |
| NCBI Protein Information: | glutathione S-transferase Mu 4 |
| UniProt Protein Name: | Glutathione S-transferase Mu 4 |
| UniProt Synonym Protein Names: | GST class-mu 4; GST-Mu2; GSTM4-4 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTM4�� |
| UniProt Entry Name: | GSTM4_HUMAN |
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