Human GSTM2 Recombinant Protein (RPPB1765)
- SKU:
- RPPB1765
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P28161
- Research Area:
- Enzymes
Description
| Product Name: | Human GSTM2 Recombinant Protein |
| Product Code: | RPPB1765 |
| Size: | 20µg |
| Species: | Human |
| Target: | GSTM2 |
| Synonyms: | Glutathione S-transferase Mu 2, GST class-mu 2, GSTM2-2, GSTM2, GST4, GSTM, GTHMUS, MGC117303. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GSTM2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol,0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEG LEKISAYMKS SRFLPRPVFT KMAVWGNK |
| Biological Activity: | Specific activity is < 25 units/mg, and is defined as the amount of enzyme that conjugate 1.0 �mole of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25�C. |
Glutathione S-transferase Mu 2 (GSTM2) belongs to the glutathione s-transferase (GST) family of proteins. GSTM2 is a glutathione S-transferase that belongs to the mu class. There are 8 families of GST proteins, specifically: alpha, kappa, mu, omega, pi, sigma, theta and zeta, each of which is composed of proteins that have various functions throughout the cell. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are structured in a gene cluster on chromosome 1p13.3 and are proven to be highly polymorphic. These genetic variants can change an individual''s susceptibility to carcinogens and toxins as well as have an effect on the toxicity and efficacy of several drugs.
GSTM2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 238 amino acids (1-218 a.a.) and having a molecular mass of 27.9kDa. The GSTM2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GSTM2: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Mu family. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.5.1.18; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: sarcoplasmic reticulum; cytoplasm; cytosol Molecular Function:protein homodimerization activity; enzyme binding; glutathione transferase activity; glutathione binding; receptor binding Biological Process: regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; glutathione metabolic process; nitrobenzene metabolic process; xenobiotic metabolic process; xenobiotic catabolic process |
| NCBI Summary: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28161 |
| NCBI GenInfo Identifier: | 232204 |
| NCBI Gene ID: | 2946 |
| NCBI Accession: | P28161.2 |
| UniProt Secondary Accession: | P28161,Q2M318, Q5TZY5, Q8WWE1, B4DRY4, E9PEM9, |
| UniProt Related Accession: | P28161 |
| Molecular Weight: | 218 |
| NCBI Full Name: | Glutathione S-transferase Mu 2 |
| NCBI Synonym Full Names: | glutathione S-transferase mu 2 (muscle) |
| NCBI Official Symbol: | GSTM2�� |
| NCBI Official Synonym Symbols: | GST4; GSTM; GTHMUS; GSTM2-2�� |
| NCBI Protein Information: | glutathione S-transferase Mu 2; GST, muscle; GST class-mu 2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-aryltransferase M2; glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase M2; S-(hydroxyalkyl)glutathione lyase M2; glutathione S-transferase M2 (muscle) |
| UniProt Protein Name: | Glutathione S-transferase Mu 2 |
| UniProt Synonym Protein Names: | GST class-mu 2; GSTM2-2 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTM2�� |
| UniProt Entry Name: | GSTM2_HUMAN |
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