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Human GSTK1 Recombinant Protein (RPPB1760)

SKU:
RPPB1760
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y2Q3
Research Area:
Enzymes
€309
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Description

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Product Name:Human GSTK1 Recombinant Protein
Product Code:RPPB1760
Size:50µg
Species:Human
Target:GSTK1
Synonyms:GST13, GST13-13, GSTK1-1, GST class-kappa, EC 2.5.1.18, Glutathione S-transferase kappa 1, Glutathione S-transferase subunit 13, hGSTK1, GSTK1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:GSTK1 solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGPLPRTVEL FYDVLSPYSW LGFEILCRYQ NIWNINLQLR PSLITGIMKD SGNKPPGLLP RKGLYMANDL KLLRHHLQIP IHFPKDFLSV MLEKGSLSAM RFLTAVNLEH PEMLEKASRE LWMRVWSRNE DITEPQSILA AAEKAGMSAE QAQGLLEKIA TPKVKNQLKE TTEAACRYGA FGLPITVAHV DGQTHMLFGS DRMELLAHLL GEKWMGPIPP AVNARL

GSTK1 is involved in cellular detoxification. GSTK1 is localized to the peroxisome and catalyzes the conjugation of the thiol group of glutathione (GSH) to the electrophilic groups of a broad range of hydrophobic substrates, leading to an easier removal of the latter from the cells.

GSTK1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 226 amino acids (1-226 a.a.) and having a molecular mass of 25.5 kDa. GSTK1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:GSTK1: Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). Belongs to the GST superfamily. Kappa family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Transferase; Mitochondrial; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: membrane; intracellular membrane-bound organelle; mitochondrial matrix; mitochondrial inner membrane; peroxisome; intracellular

Molecular Function:glutathione transferase activity; protein disulfide oxidoreductase activity; glutathione peroxidase activity; receptor binding

Biological Process: glutathione metabolic process; epithelial cell differentiation

NCBI Summary:This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
UniProt Code:Q9Y2Q3
NCBI GenInfo Identifier:12643338
NCBI Gene ID:373156
NCBI Accession:Q9Y2Q3.3
UniProt Secondary Accession:Q9Y2Q3,Q6P4H0, Q7Z520, Q9P1S4, B4DIH1, B4DSY2,
UniProt Related Accession:Q9Y2Q3
Molecular Weight:226
NCBI Full Name:Glutathione S-transferase kappa 1
NCBI Synonym Full Names:glutathione S-transferase kappa 1
NCBI Official Symbol:GSTK1��
NCBI Official Synonym Symbols:GST; GST13; hGSTK1; GSTK1-1; GST13-13; GST 13-13��
NCBI Protein Information:glutathione S-transferase kappa 1; GST class-kappa; glutathione S-transferase k1; glutathione S-transferase subunit 13 homolog
UniProt Protein Name:Glutathione S-transferase kappa 1
UniProt Synonym Protein Names:GST 13-13; GST class-kappa; GSTK1-1; hGSTK1; Glutathione S-transferase subunit 13
Protein Family:Glutathione S-transferase
UniProt Gene Name:GSTK1��
UniProt Entry Name:GSTK1_HUMAN

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